Show simple item record

dc.creatorLam, TTY
dc.creatorHon, CC
dc.creatorPybus, OG
dc.creatorKosakovsky Pond, SL
dc.creatorWong, RTY
dc.creatorYip, CW
dc.creatorZeng, F
dc.creatorLeung, FCC
dc.date.accessioned2021-02-01T21:55:11Z
dc.date.available2021-02-01T21:55:11Z
dc.date.issued2008-08-01
dc.identifier.issn1553-7366
dc.identifier.issn1553-7374
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5585
dc.identifier.other18725937 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5603
dc.description.abstractH5N1 highly pathogenic avian influenza (HPAI) viruses have seriously affected the Asian poultry industry since their recurrence in 2003. The viruses pose a threat of emergence of a global pandemic influenza through point mutation or reassortment leading to a strain that can effectively transmit among humans. In this study, we present phylogenetic evidences for the interlineage reassortment among H5N1 HPAI viruses isolated from humans, cats, and birds in Indonesia, and identify the potential genetic parents of the reassorted genome segments. Parsimony analyses of viral phylogeography suggest that the reassortant viruses may have originated from greater Jakarta and surroundings, and subsequently spread to other regions in the West Java province. In addition, Bayesian methods were used to elucidate the genetic diversity dynamics of the reassortant strain and one of its genetic parents, which revealed a more rapid initial growth of genetic diversity in the reassortant viruses relative to their genetic parent. These results demonstrate that interlineage exchange of genetic information may play a pivotal role in determining viral genetic diversity in a focal population. Moreover, our study also revealed significantly stronger diversifying selection on the M1 and PB2 genes in the lineages preceding and subsequent to the emergence of the reassortant viruses, respectively. We discuss how the corresponding mutations might drive the adaptation and onward transmission of the newly formed reassortant viruses. © 2008 Lam et al.
dc.format.extente1000130-e1000130
dc.language.isoen
dc.relation.haspartPLoS Pathogens
dc.relation.isreferencedbyPublic Library of Science (PLoS)
dc.rightsCC BY
dc.subjectAnimals
dc.subjectEvolution, Molecular
dc.subjectGenes, Viral
dc.subjectHumans
dc.subjectIndonesia
dc.subjectInfluenza A Virus, H5N1 Subtype
dc.subjectInfluenza in Birds
dc.subjectPoultry
dc.subjectPoultry Diseases
dc.titleEvolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1371/journal.ppat.1000130
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidPond, Sergei L. Kosakovsky|0000-0003-4817-4029
dc.date.updated2021-02-01T21:55:08Z
refterms.dateFOA2021-02-01T21:55:12Z


Files in this item

Thumbnail
Name:
Evolutionary and transmission ...
Size:
454.9Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record