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dc.creatorNg, Tommy H.
dc.creatorAlloy, Lauren B.
dc.creatorSmith, David
dc.date.accessioned2020-04-20T16:23:03Z
dc.date.available2020-04-20T16:23:03Z
dc.date.issued2019-08-09
dc.identifier.citationNg, T.H., Alloy, L.B. & Smith, D.V. Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit. Transl Psychiatry 9, 293 (2019). https://doi.org/10.1038/s41398-019-0644-x
dc.identifier.issn2158-3188
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/42
dc.identifier.urihttp://hdl.handle.net/20.500.12613/55
dc.description.abstractMany neuroimaging studies have investigated reward processing dysfunction in major depressive disorder. These studies have led to the common idea that major depressive disorder is associated with blunted responses within the reward circuit, particularly in the ventral striatum. Yet, the link between major depressive disorder and reward-related responses in other regions remains inconclusive, thus limiting our understanding of the pathophysiology of major depressive disorder. To address this issue, we performed a coordinate-based meta-analysis of 41 whole-brain neuroimaging studies encompassing reward-related responses from a total of 794 patients with major depressive disorder and 803 healthy controls. Our findings argue against the common idea that major depressive disorder is primarily linked to deficits within the reward system. Instead, our results demonstrate that major depressive disorder is associated with opposing abnormalities in the reward circuit: hypo-responses in the ventral striatum and hyper-responses in the orbitofrontal cortex. The current findings suggest that dysregulated corticostriatal connectivity may underlie reward-processing abnormalities in major depressive disorder, providing an empirical foundation for a more refined understanding of abnormalities in the reward circuitry in major depressive disorder.
dc.format.extent10 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofOpen Access Publishing Fund (OAPF)
dc.relation.haspartTranslational Psychiatry, Vol. 9, Article number: 293
dc.relation.isreferencedbySpringer Nature
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDepression
dc.subjectDiagnostic markers
dc.subjectHuman behaviour
dc.titleMeta-analysis of Reward Processing in Major Depressive Disorder Reveals Distinct Abnormalities within the Reward Circuit
dc.typeText
dc.type.genreJournal article
dc.description.departmentPsychology
dc.relation.doihttps://doi.org/10.1038/s41398-019-0644-x
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Liberal Arts
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2019-2020 (Philadelphia, Pa.)
dc.description.sponsorNational Institutes of Health (U.S.)
dc.creator.orcid0000-0001-5754-9633
dc.temple.creatorNg, Tommy H.
dc.temple.creatorAlloy, Lauren B.
dc.temple.creatorSmith, David V.
refterms.dateFOA2020-04-20T16:23:03Z


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