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    Latitudinal clines of the human vitamin D receptor and skin color genes

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    Name:
    Latitudinal Clines of the Human ...
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    Genre
    Journal Article
    Date
    2016-05-01
    Author
    Tiosano, D
    Audi, L
    Climer, S
    Zhang, W
    Templeton, AR
    Fernández-Cancio, M
    Gershoni-Baruch, R
    Sánchez-Muro, JM
    El Kholy, M
    Hochberg, Z
    Subject
    adaptation
    epistasis
    linkage disequilibrium
    network analysis
    skin color
    vitamin D
    Adaptation, Biological
    Alleles
    Altitude
    Computational Biology
    Epistasis, Genetic
    Gene Frequency
    Gene Regulatory Networks
    Gene-Environment Interaction
    Genetic Linkage
    Genome, Human
    Genomics
    Genotype
    Humans
    Linkage Disequilibrium
    Polymorphism, Single Nucleotide
    Receptors, Calcitriol
    Skin Pigmentation
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    Permanent link to this record
    http://hdl.handle.net/20.500.12613/5584
    
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    DOI
    10.1534/g3.115.026773
    Abstract
    © 2016 Tiosano et al. The well-documented latitudinal clines of genes affecting human skin color presumably arise from the need for protection from intense ultraviolet radiation (UVR) vs. the need to use UVR for vitamin D synthesis. Sampling 751 subjects from a broad range of latitudes and skin colors, we investigated possible multilocus correlated adaptation of skin color genes with the vitamin D receptor gene (VDR), using a vector correlation metric and network method called BlocBuster. We discovered two multilocus networks involving VDR promoter and skin color genes that display strong latitudinal clines as multilocus networks, even though many of their single gene components do not. Considered one by one, the VDR components of these networks show diverse patterns: no cline, a weak declining latitudinal cline outside of Africa, and a strong in- vs. out-of-Africa frequency pattern. We confirmed these results with independent data from HapMap. Standard linkage disequilibrium analyses did not detect these networks. We applied BlocBuster across the entire genome, showing that our networks are significant outliers for interchromosomal disequilibrium that overlap with environmental variation relevant to the genes' functions. These results suggest that these multilocus correlations most likely arose from a combination of parallel selective responses to a common environmental variable and coadaptation, given the known Mendelian epistasis among VDR and the skin color genes.
    Citation to related work
    Oxford University Press (OUP)
    Has part
    G3: Genes, Genomes, Genetics
    ADA compliance
    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/5566
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