Show simple item record

dc.creatorCompton, SN
dc.creatorWalkup, JT
dc.creatorAlbano, AM
dc.creatorPiacentini, JC
dc.creatorBirmaher, B
dc.creatorSherrill, JT
dc.creatorGinsburg, GS
dc.creatorRynn, MA
dc.creatorMcCracken, JT
dc.creatorWaslick, BD
dc.creatorIyengar, S
dc.creatorKendall, PC
dc.creatorMarch, JS
dc.date.accessioned2021-02-01T00:11:55Z
dc.date.available2021-02-01T00:11:55Z
dc.date.issued2010-01-05
dc.identifier.issn1753-2000
dc.identifier.issn1753-2000
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5532
dc.identifier.otherPMC2818613 (pmc)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5550
dc.description.abstractObjective: To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study (CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavior therapy (CBT), sertraline (SRT), and their combination (COMB) against pill placebo (PBO) for the treatment of separation anxiety disorder (SAD), generalized anxiety disorder (GAD) and social phobia (SoP) in children and adolescents.Methods: Following a brief review of the acute outcomes of the CAMS trial, as well as the psychosocial and pharmacologic treatment literature for pediatric anxiety disorders, the design and methods of the CAMS trial are described.Results: CAMS was a six-year, six-site, randomized controlled trial. Four hundred eighty-eight (N = 488) children and adolescents (ages 7-17 years) with DSM-IV-TR diagnoses of SAD, GAD, or SoP were randomly assigned to one of four treatment conditions: CBT, SRT, COMB, or PBO. Assessments of anxiety symptoms, safety, and functional outcomes, as well as putative mediators and moderators of treatment response were completed in a multi-measure, multi-informant fashion. Manual-based therapies, trained clinicians and independent evaluators were used to ensure treatment and assessment fidelity. A multi-layered administrative structure with representation from all sites facilitated cross-site coordination of the entire trial, study protocols and quality assurance.Conclusions: CAMS offers a model for clinical trials methods applicable to psychosocial and psychopharmacological comparative treatment trials by using state-of-the-art methods and rigorous cross-site quality controls. CAMS also provided a large-scale examination of the relative and combined efficacy and safety of the best evidenced-based psychosocial (CBT) and pharmacologic (SSRI) treatments to date for the most commonly occurring pediatric anxiety disorders. Primary and secondary results of CAMS will hold important implications for informing practice-relevant decisions regarding the initial treatment of youth with anxiety disorders.Trial registration: ClinicalTrials.gov NCT00052078. © 2010 Compton et al; licensee BioMed Central Ltd.
dc.format.extent1-
dc.language.isoen
dc.relation.haspartChild and Adolescent Psychiatry and Mental Health
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.subject1701 Psychology
dc.subject1103 Clinical Sciences
dc.subject1117 Public Health and Health Services
dc.subjectClinical
dc.subjectClinical Medicine and Science
dc.subjectAnxiety Disorders
dc.subjectPediatric
dc.subjectClinical Research
dc.subjectBrain Disorders
dc.subjectPatient Safety
dc.subjectBehavioral and Social Science
dc.subjectMental Health
dc.subjectClinical Trials and Supportive Activities
dc.subjectMental Health
dc.subject6.1 Pharmaceuticals
dc.subject6.6 Psychological and behavioural
dc.titleChild/Adolescent Anxiety Multimodal Study (CAMS): Rationale, design, and methods
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.1186/1753-2000-4-1
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-02-01T00:11:52Z
refterms.dateFOA2021-02-01T00:11:56Z


Files in this item

Thumbnail
Name:
ChildAdolescent Anxiety Multimodal ...
Size:
351.2Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record