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    Child/Adolescent Anxiety Multimodal Study (CAMS): Rationale, design, and methods

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    Name:
    ChildAdolescent Anxiety Multimodal ...
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    Genre
    Review
    Journal
    Date
    2010-01-05
    Author
    Compton, SN
    Walkup, JT
    Albano, AM
    Piacentini, JC
    Birmaher, B
    Sherrill, JT
    Ginsburg, GS
    Rynn, MA
    McCracken, JT
    Waslick, BD
    Iyengar, S
    Kendall, PC
    March, JS
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    Subject
    1701 Psychology
    1103 Clinical Sciences
    1117 Public Health and Health Services
    Clinical
    Clinical Medicine and Science
    Anxiety Disorders
    Pediatric
    Clinical Research
    Brain Disorders
    Patient Safety
    Behavioral and Social Science
    Mental Health
    Clinical Trials and Supportive Activities
    Mental Health
    6.1 Pharmaceuticals
    6.6 Psychological and behavioural
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    Permanent link to this record
    http://hdl.handle.net/20.500.12613/5550
    
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    DOI
    10.1186/1753-2000-4-1
    Abstract
    Objective: To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study (CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavior therapy (CBT), sertraline (SRT), and their combination (COMB) against pill placebo (PBO) for the treatment of separation anxiety disorder (SAD), generalized anxiety disorder (GAD) and social phobia (SoP) in children and adolescents.Methods: Following a brief review of the acute outcomes of the CAMS trial, as well as the psychosocial and pharmacologic treatment literature for pediatric anxiety disorders, the design and methods of the CAMS trial are described.Results: CAMS was a six-year, six-site, randomized controlled trial. Four hundred eighty-eight (N = 488) children and adolescents (ages 7-17 years) with DSM-IV-TR diagnoses of SAD, GAD, or SoP were randomly assigned to one of four treatment conditions: CBT, SRT, COMB, or PBO. Assessments of anxiety symptoms, safety, and functional outcomes, as well as putative mediators and moderators of treatment response were completed in a multi-measure, multi-informant fashion. Manual-based therapies, trained clinicians and independent evaluators were used to ensure treatment and assessment fidelity. A multi-layered administrative structure with representation from all sites facilitated cross-site coordination of the entire trial, study protocols and quality assurance.Conclusions: CAMS offers a model for clinical trials methods applicable to psychosocial and psychopharmacological comparative treatment trials by using state-of-the-art methods and rigorous cross-site quality controls. CAMS also provided a large-scale examination of the relative and combined efficacy and safety of the best evidenced-based psychosocial (CBT) and pharmacologic (SSRI) treatments to date for the most commonly occurring pediatric anxiety disorders. Primary and secondary results of CAMS will hold important implications for informing practice-relevant decisions regarding the initial treatment of youth with anxiety disorders.Trial registration: ClinicalTrials.gov NCT00052078. © 2010 Compton et al; licensee BioMed Central Ltd.
    Citation to related work
    Springer Science and Business Media LLC
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    Child and Adolescent Psychiatry and Mental Health
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    http://dx.doi.org/10.34944/dspace/5532
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      Psychosocial Characteristics and Gestational Weight Change among Overweight, African American Pregnant Women

      Allison, Kelly C; Wrotniak, Brian H; Paré, Emmanuelle; Sarwer, David B; Sarwer, David B|0000-0003-1033-5528 (2012)
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