Show simple item record

dc.creatorKrief, S
dc.creatorEscalante, AA
dc.creatorPacheco, MA
dc.creatorMugisha, L
dc.creatorAndré, C
dc.creatorHalbwax, M
dc.creatorFischer, A
dc.creatorKrief, JM
dc.creatorKasenene, JM
dc.creatorCrandfield, M
dc.creatorCornejo, OE
dc.creatorChavatte, JM
dc.creatorLin, C
dc.creatorLetourneur, F
dc.creatorGrüner, AC
dc.creatorMcCutchan, TF
dc.creatorRénia, L
dc.creatorSnounou, G
dc.date.accessioned2021-02-01T00:10:29Z
dc.date.available2021-02-01T00:10:29Z
dc.date.issued2010-02-01
dc.identifier.issn1553-7366
dc.identifier.issn1553-7374
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5530
dc.identifier.other20169187 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5548
dc.description.abstractThe origin of Plasmodium falciparum, the etiological agent of the most dangerous forms of human malaria, remains controversial. Although investigations of homologous parasites in African Apes are crucial to resolve this issue, studies have been restricted to a chimpanzee parasite related to P. falciparum, P. reichenowi, for which a single isolate was available until very recently. Using PCR amplification, we detected Plasmodium parasites in blood samples from 18 of 91 individuals of the genus Pan, including six chimpanzees (three Pan troglodytes troglodytes, three Pan t. schweinfurthii) and twelve bonobos (Pan paniscus). We obtained sequences of the parasites' mitochondrial genomes and/or from two nuclear genes from 14 samples. In addition to P. reichenowi, three other hitherto unknown lineages were found in the chimpanzees. One is related to P. vivax and two to P. falciparum that are likely to belong to distinct species. In the bonobos we found P. falciparum parasites whose mitochondrial genomes indicated that they were distinct from those present in humans, and another parasite lineage related to P. malariae. Phylogenetic analyses based on this diverse set of Plasmodium parasites in African Apes shed new light on the evolutionary history of P. falciparum. The data suggested that P. falciparum did not originate from P. reichenowi of chimpanzees (Pan troglodytes), but rather evolved in bonobos (Pan paniscus), from which it subsequently colonized humans by a host-switch. Finally, our data and that of others indicated that chimpanzees and bonobos maintain malaria parasites, to which humans are susceptible, a factor of some relevance to the renewed efforts to eradicate malaria.
dc.format.extente1000765-e1000765
dc.language.isoen
dc.relation.haspartPLoS Pathogens
dc.relation.isreferencedbyPublic Library of Science (PLoS)
dc.subjectAnimals
dc.subjectGenes, Protozoan
dc.subjectHumans
dc.subjectMalaria, Falciparum
dc.subjectPan paniscus
dc.subjectPan troglodytes
dc.subjectPhylogeny
dc.subjectPlasmodium falciparum
dc.subjectPolymerase Chain Reaction
dc.titleOn the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from bonobos
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1371/journal.ppat.1000765
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-02-01T00:10:25Z
refterms.dateFOA2021-02-01T00:10:29Z


Files in this item

Thumbnail
Name:
On the diversity of malaria ...
Size:
682.9Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record