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dc.contributor.advisorWong, Ho-Lun
dc.creatorLuan, Shijie
dc.date.accessioned2020-10-16T13:57:03Z
dc.date.available2020-10-16T13:57:03Z
dc.date.issued2020
dc.identifier.urihttp://hdl.handle.net/20.500.12613/550
dc.description.abstractThe peritoneal tumor is not named after the originating of cancer cells but instead contains all tumors appearing in the region of the peritoneal cavity. There are over 250,000 new cases of malignant diseases originating from organs in the peritoneal cavity annually in the USA, and most of these cases spread by intraperitoneal seeding. Cytoreductive surgery for removal and debulking of metastases in the peritoneal cavity is the primary treatment option. Complete surgical removal of the cancerous tissues, however, is difficult to achieve because positive margins are often left behind, and it is difficult to detect the small metastases in the peritoneal cavity. Methyl aminolevulinate (MAL), a protoporphyrin X (PplX) prodrug, has been clinically used for photodynamic therapy of local malignancies such as Basal Cell Carcinoma and Actinic Keratosis. Its application for cancers in the peritoneal cavity, however, has been limited by its non-specific biodistribution and adverse effects. Since nanoparticles can play an essential role as drug deliver platforms as a result of their loading capacity, sustained drug release profile, and potential targeting ability, I proposed a liposomal delivery system, Folic-modified liposome (FL). The goal of this study is to take advantage of this observation by developing a FL system of MAL for photodynamic diagnosis and therapy of cancers in the peritoneal cavity in a more specific and efficient manner. Based on the results presented, FL has the potential to improve cytoreductive surgery in the following manner: a) A hydrophilic core can encapsulate high amounts of MAL and protect it from metabolic degradation; b) FL systems loaded with MAL can enlarge the gap between PpIX accumulation in tumor cells and normal tissues. c) FL system loaded with MAL can provide photodynamic diagnosis and photodynamic therapy as complementary functions.
dc.format.extent153 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectPharmaceutical Sciences
dc.subjectDrug Delivery System
dc.subjectLiposome
dc.subjectMethyl Aminolevulinate
dc.subjectPeritoneal Cancer
dc.subjectPhotodynamic Dignosis
dc.subjectPhotodynamic Therapy
dc.titleA cancer-targeting liposomal delivery system for photodynamic diagnosis and therapy of cancers in peritoneal cavity
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberBlass, Benjamin E.
dc.contributor.committeememberFassihi, Reza
dc.contributor.committeememberShoyele, Sunday
dc.description.departmentPharmaceutical Sciences
dc.relation.doihttp://dx.doi.org/10.34944/dspace/532
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreePh.D.
refterms.dateFOA2020-10-16T13:57:03Z
dc.embargo.lift06/04/2021


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