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dc.creatorRota, R
dc.creatorCiarapica, R
dc.creatorGiordano, A
dc.creatorMiele, L
dc.creatorLocatelli, F
dc.date.accessioned2021-01-31T23:22:34Z
dc.date.available2021-01-31T23:22:34Z
dc.date.issued2011-09-24
dc.identifier.issn1476-4598
dc.identifier.issn1476-4598
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5482
dc.identifier.other21943149 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5500
dc.description.abstractThere is growing evidence that interconnections among molecular pathways governing tissue differentiation are nodal points for malignant transformation. In this scenario, microRNAs appear as crucial players. This class of non-coding small regulatory RNA molecules controls developmental programs by modulating gene expression through post-transcriptional silencing of target mRNAs. During myogenesis, muscle-specific and ubiquitously-expressed microRNAs tightly control muscle tissue differentiation. In recent years, microRNAs have emerged as prominent players in cancer as well. Rhabdomyosarcoma is a pediatric skeletal muscle-derived soft-tissue sarcoma that originates from myogenic precursors arrested at different stages of differentiation and that continue to proliferate indefinitely. MicroRNAs involved in muscle cell fate determination appear down-regulated in rhabdomyosarcoma primary tumors and cell lines compared to their normal counterparts. More importantly, they behave as tumor suppressors in this malignancy, as their re-expression is sufficient to restore the differentiation capability of tumor cells and to prevent tumor growth in vivo. In addition, up-regulation of pro-oncogenic microRNAs has also been recently detected in rhabdomyosarcoma.In this review, we provide an overview of current knowledge on microRNAs de-regulation in rhabdomyosarcoma. Additionally, we examine the potential of microRNAs as prognostic and diagnostic markers in this soft-tissue sarcoma, and discuss possible therapeutic applications and challenges of a "microRNA therapy". © 2011 Rota et al; licensee BioMed Central Ltd.
dc.format.extent120-120
dc.language.isoen
dc.relation.haspartMolecular Cancer
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectCell Differentiation
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectHumans
dc.subjectMicroRNAs
dc.subjectMuscle Development
dc.subjectMuscle, Skeletal
dc.subjectPolycomb-Group Proteins
dc.subjectRepressor Proteins
dc.subjectRhabdomyosarcoma
dc.titleMicroRNAs in rhabdomyosarcoma: Pathogenetic implications and translational potentiality
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.1186/1476-4598-10-120
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidGiordano, Antonio|0000-0002-5959-016X
dc.date.updated2021-01-31T23:22:30Z
refterms.dateFOA2021-01-31T23:22:34Z


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