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dc.creatorChan, Marion M.
dc.creatorYang, Xiaofeng
dc.creatorSaaoud, Fatma
dc.creatorSun, Yu
dc.creatorFong, Dunne
dc.creatorWang, Hong
dc.date.accessioned2020-04-20T16:23:03Z
dc.date.available2020-04-20T16:23:03Z
dc.date.issued2019-08-07
dc.identifier.citationChan, M.M.; Yang, X.; Wang, H.; Saaoud, F.; Sun, Y.; Fong, D. The Microbial Metabolite Trimethylamine N-Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis. Nutrients 2019, 11, 1821.
dc.identifier.issn2072-6643
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/41
dc.identifier.urihttp://hdl.handle.net/20.500.12613/54
dc.description.abstractDiet and microbiota each have a direct impact on many chronic, inflammatory, and metabolic diseases. As the field develops, a new perspective is emerging. The effects of diet may depend on the microbiota composition of the intestine. A diet that is rich in choline, red meat, dairy, or egg may promote the growth, or change the composition, of microbial species. The microbiota, in turn, may produce metabolites that increase the risk of cardiovascular disease. This article reviews our current understanding of the effects of the molecule trimethylamine-N-oxide (TMAO) obtained from food or produced by the microbiota. We review the mechanisms of actions of TMAO, and studies that associate it with cardiovascular and chronic kidney diseases. We introduce a novel concept: TMAO is one among a group of selective uremic toxins that may rise to high levels in the circulation or accumulate in various organs. Based on this information, we evaluate how TMAO may harm, by exacerbating inflammation, or may protect, by attenuating amyloid formation, in autoimmune diseases such as rheumatoid arthritis.
dc.format.extent18 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofOpen Access Publishing Fund (OAPF)
dc.relation.haspartNutrients, Vol. 11, Issue 8, 1821
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTrimethylamine-N-oxide
dc.subjectCardiovascular disease
dc.subjectRheumatoid arthritis
dc.titleThe Microbial Metabolite Trimethylamine N-Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis
dc.typeText
dc.type.genreJournal article
dc.contributor.groupCenter for Inflammation, Translational and Clinical Lung Research
dc.contributor.groupCenter for Metabolic Disease Research
dc.description.departmentMicrobiology and Immunology
dc.relation.doihttps://doi.org/10.3390/nu11081821
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2019-2020 (Philadelphia, Pa.)
dc.creator.orcid0000-0001-6258-4070
dc.creator.orcid0000-0001-6258-4070
dc.temple.creatorChan, Marion M.
dc.temple.creatorYang, Xiaofeng
dc.temple.creatorWang, Hong
dc.temple.creatorSaaoud, Fatma
dc.temple.creatorSun, Yu
refterms.dateFOA2020-04-20T16:23:03Z


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