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dc.contributor.advisorGallucci, Stefania
dc.creatorLee, Michael Hweemoon
dc.date.accessioned2020-10-16T13:57:02Z
dc.date.available2020-10-16T13:57:02Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/20.500.12613/548
dc.description.abstractSystemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies directed against ubiquitous self-antigens, many of which are nuclear autoantigens like dsDNA and chromatin (Pisetsky, 2016), and by elevated type I interferons (IFN) (Hooks et al., 1979; Weckerle et al., 2011), a family of pro-inflammatory cytokines that have antiviral activity (Pestka et al., 2004). Microarray analysis of peripheral blood mononuclear cells (PBMC) from SLE patients discovered the increased expression of IFN-responsive genes that was named the IFN Signature (Baechler et al., 2003a; Bennett et al., 2003b; Crow et al., 2003). Genome wide association studies indicate a clear genetic component in lupus pathogenesis (Chung et al., 2011; SLEGEN et al., 2008) and murine models of SLE confirm genetic drivers of the disease (Morel, 2010; Morel et al., 2000). However, the concordance of SLE in monozygotic twins is only 30-40% (Connolly and Hakonarson, 2012), while the inc
dc.format.extent233 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectImmunology
dc.subjectAutoimmunity
dc.subjectB Cells
dc.subjectCurli
dc.subjectDendritic Cells
dc.subjectSle
dc.titleModulators of Dendritic Cells and B cells in Lupus
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberCaricchio, Roberto
dc.contributor.committeememberMonestier, Marc
dc.contributor.committeememberTükel, Çagla
dc.contributor.committeememberZhang, Yi
dc.contributor.committeememberLuning Prak, Eline T.
dc.description.departmentMicrobiology and Immunology
dc.relation.doihttp://dx.doi.org/10.34944/dspace/530
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreePh.D.
refterms.dateFOA2020-10-16T13:57:02Z
dc.embargo.lift05/17/2021


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