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dc.creatorChenet, SM
dc.creatorTapia, LL
dc.creatorEscalante, AA
dc.creatorDurand, S
dc.creatorLucas, C
dc.creatorBacon, DJ
dc.date.accessioned2021-01-31T22:34:45Z
dc.date.available2021-01-31T22:34:45Z
dc.date.issued2012-03-15
dc.identifier.issn1475-2875
dc.identifier.issn1475-2875
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5455
dc.identifier.other22417572 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5473
dc.description.abstractBackground: A major concern in malaria vaccine development is genetic polymorphisms typically observed among Plasmodium isolates in different geographical areas across the world. Highly polymorphic regions have been observed in Plasmodium falciparum and Plasmodium vivax antigenic surface proteins such as Circumsporozoite protein (CSP), Duffy-binding protein (DBP), Merozoite surface protein-1 (MSP-1), Apical membrane antigen-1 (AMA-1) and Thrombospondin related anonymous protein (TRAP). Methods. Genetic variability was assessed in important polymorphic regions of various vaccine candidate antigens in P. vivax among 106 isolates from the Amazon Region of Loreto, Peru. In addition, genetic diversity determined in Peruvian isolates was compared to population studies from various geographical locations worldwide. Results: The structured diversity found in P. vivax populations did not show a geographic pattern and haplotypes from all gene candidates were distributed worldwide. In addition, evidence of balancing selection was found in polymorphic regions of the trap, dbp and ama-1 genes. Conclusions: It is important to have a good representation of the haplotypes circulating worldwide when implementing a vaccine, regardless of the geographic region of deployment since selective pressure plays an important role in structuring antigen diversity. © 2012 Chenet et al; licensee BioMed Central Ltd.
dc.format.extent68-68
dc.language.isoen
dc.relation.haspartMalaria Journal
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectMalaria
dc.subjectPlasmodium vivax
dc.subjectVaccine candidates
dc.subjectHaplotypes
dc.titleGenetic diversity and population structure of genes encoding vaccine candidate antigens of Plasmodium vivax
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1186/1475-2875-11-68
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-31T22:34:43Z
refterms.dateFOA2021-01-31T22:34:46Z


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