Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade
Genre
Journal ArticleDate
2012-09-01Author
Tachibana, SISullivan, SA
Kawai, S
Nakamura, S
Kim, HR
Goto, N
Arisue, N
Palacpac, NMQ
Honma, H
Yagi, M
Tougan, T
Katakai, Y
Kaneko, O
Mita, T
Kita, K
Yasutomi, Y
Sutton, PL
Shakhbatyan, R
Horii, T
Yasunaga, T
Barnwell, JW
Escalante, AA
Carlton, JM
Tanabe, K
Subject
AnimalsBase Sequence
Cluster Analysis
Genes, Protozoan
Genome, Protozoan
Haplorhini
Malaria
Models, Genetic
Molecular Sequence Data
Monkey Diseases
Phylogeny
Plasmodium cynomolgi
Plasmodium vivax
Sequence Analysis, DNA
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http://hdl.handle.net/20.500.12613/5455
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10.1038/ng.2375Abstract
P. cynomolgi, a malaria-causing parasite of Asian Old World monkeys, is the sister taxon of P. vivax, the most prevalent malaria-causing species in humans outside of Africa. Because P. cynomolgi shares many phenotypic, biological and genetic characteristics with P. vivax, we generated draft genome sequences for three P. cynomolgi strains and performed genomic analysis comparing them with the P. vivax genome, as well as with the genome of a third previously sequenced simian parasite, Plasmodium knowlesi. Here, we show that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes. We identify genome-wide SNPs, microsatellites and CNVs in the P. cynomolgi genome, providing a map of genetic variation that can be used to map parasite traits and study parasite populations. The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax. © 2012 Nature America, Inc. All rights reserved.Citation to related work
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http://dx.doi.org/10.34944/dspace/5437
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