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dc.creatorOates, ME
dc.creatorRomero, P
dc.creatorIshida, T
dc.creatorGhalwash, M
dc.creatorMizianty, MJ
dc.creatorXue, B
dc.creatorDosztányi, Z
dc.creatorUversky, VN
dc.creatorObradovic, Z
dc.creatorKurgan, L
dc.creatorDunker, AK
dc.creatorGough, J
dc.date.accessioned2021-01-31T21:00:06Z
dc.date.available2021-01-31T21:00:06Z
dc.date.issued2013-01-01
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5421
dc.identifier.other23203878 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5439
dc.description.abstractWe present the Database of Disordered Protein Prediction (D 2P2), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein sequences from 1765 complete proteomes (to be updated as more genomes are completed). Integrated with these results are all of the predicted (mostly structured) SCOP domains using the SUPERFAMILY predictor. These disorder/structure annotations together enable comparison of the disorder predictors with each other and examination of the overlap between disordered predictions and SCOP domains on a large scale. D2P2 will increase our understanding of the interplay between disorder and structure, the genomic distribution of disorder, and its evolutionary history. The parsed data are made available in a unified format for download as flat files or SQL tables either by genome, by predictor, or for the complete set. An interactive website provides a graphical view of each protein annotated with the SCOP domains and disordered regions from all predictors overlaid (or shown as a consensus). There are statistics and tools for browsing and comparing genomes and their disorder within the context of their position on the tree of life. © The Author(s) 2012.
dc.format.extentD508-D516
dc.language.isoen
dc.relation.haspartNucleic Acids Research
dc.relation.isreferencedbyOxford University Press (OUP)
dc.rightsCC BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.subjectDatabases, Protein
dc.subjectGenome
dc.subjectInternet
dc.subjectProtein Conformation
dc.subjectProtein Structure, Tertiary
dc.subjectProteins
dc.subjectSequence Analysis, Protein
dc.titleD<sup>2</sup>P<sup>2</sup>: Database of disordered protein predictions
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1093/nar/gks1226
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-31T21:00:00Z
refterms.dateFOA2021-01-31T21:00:06Z


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