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dc.creatorMoser, AB
dc.creatorHey, J
dc.creatorDranchak, PK
dc.creatorKaraman, MW
dc.creatorZhao, J
dc.creatorCox, LA
dc.creatorRyder, OA
dc.creatorHacia, JG
dc.date.accessioned2021-01-31T20:31:12Z
dc.date.available2021-01-31T20:31:12Z
dc.date.issued2013-02-06
dc.identifier.issn1476-511X
dc.identifier.issn1476-511X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5395
dc.identifier.other23379307 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5413
dc.description.abstractBackground: Humans and rodents with impaired phytanic acid (PA) metabolism can accumulate toxic stores of PA that have deleterious effects on multiple organ systems. Ruminants and certain fish obtain PA from the microbial degradation of dietary chlorophyll and/or through chlorophyll-derived precursors. In contrast, humans cannot derive PA from chlorophyll and instead normally obtain it only from meat, dairy, and fish products. Results: Captive apes and Old world monkeys had significantly higher red blood cell (RBC) PA levels relative to humans when all subjects were fed PA-deficient diets. Given the adverse health effects resulting from PA over accumulation, we investigated the molecular evolution of thirteen PA metabolism genes in apes, Old world monkeys, and New world monkeys. All non-human primate (NHP) orthologs are predicted to encode full-length proteins with the marmoset Phyh gene containing a rare, but functional, GA splice donor dinucleotide. Acox2, Scp2, and Pecr sequences had amino acid positions with accelerated substitution rates while Amacr had significant variation in evolutionary rates in apes relative to other primates. Conclusions: Unlike humans, diverse captive NHPs with PA-deficient diets rich in plant products have substantial RBC PA levels. The favored hypothesis is that NHPs can derive significant amounts of PA from the degradation of ingested chlorophyll through gut fermentation. If correct, this raises the possibility that RBC PA levels could serve as a biomarker for evaluating the digestive health of captive NHPs. Furthermore, the evolutionary rates of the several genes relevant to PA metabolism provide candidate genetic adaptations to NHP diets. © 2013 Moser et al.; licensee BioMed Central Ltd.
dc.format.extent10-10
dc.language.isoen
dc.relation.haspartLipids in Health and Disease
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectAnimals
dc.subjectBiological Evolution
dc.subjectCallithrix
dc.subjectCarrier Proteins
dc.subjectChlorophyll
dc.subjectDiet, Vegetarian
dc.subjectErythrocytes
dc.subjectFemale
dc.subjectGene Expression
dc.subjectHominidae
dc.subjectHumans
dc.subjectMacaca mulatta
dc.subjectMale
dc.subjectMixed Function Oxygenases
dc.subjectOxidoreductases
dc.subjectOxidoreductases Acting on CH-CH Group Donors
dc.subjectPapio anubis
dc.subjectPhytanic Acid
dc.subjectRacemases and Epimerases
dc.subjectSpecies Specificity
dc.titleDiverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1186/1476-511X-12-10
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-31T20:31:08Z
refterms.dateFOA2021-01-31T20:31:12Z


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