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dc.creatorAnné, J
dc.creatorEdwards, NP
dc.creatorWogelius, RA
dc.creatorTumarkin-Deratzian, AR
dc.creatorSellers, WI
dc.creatorVan Veelen, A
dc.creatorBergmann, U
dc.creatorSokaras, D
dc.creatorAlonso-Mori, R
dc.creatorIgnatyev, K
dc.creatorEgerton, VM
dc.creatorManning, PL
dc.date.accessioned2021-01-31T17:02:27Z
dc.date.available2021-01-31T17:02:27Z
dc.date.issued2014-07-06
dc.identifier.issn1742-5689
dc.identifier.issn1742-5662
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5282
dc.identifier.other24806709 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5300
dc.description.abstractCurrent understanding of bone healing andremodelling strategies in vertebrates has traditionally relied on morphological observations through the histological analysis of thin sections. However, chemical analysis may also be used in such interpretations, as different elements are known to be absorbed and used by bone for different physiological purposes such as growth and healing. These chemical signatures are beyond the detection limit of most laboratory-based analytical techniques (e.g. scanning electron microscopy). However, synchrotron rapid scanning-X-ray fluorescence (SRS-XRF) is an elemental mapping technique that uniquely combines high sensitivity (ppm), excellent sample resolution (20-100 μm) and the ability to scan large specimens (decimetre scale) approximately 3000 times faster than other mapping techniques. Here, we use SRS-XRF combined with microfocus elemental mapping (2-20 μm) to determine the distribution and concentration of trace elements within pathological and normal bone of both extant and extinct archosaurs (Cathartes aura and Allosaurus fragilis). Results reveal discrete chemical inventories within different bone tissue types and preservation modes. Chemical inventories also revealed detail of histological features not observable in thin section, including fine structures within the interface between pathological and normal bone as well as woven texture within pathological tissue. © 2014 The Authors. Published by the Royal Society.
dc.format.extent20140277-20140277
dc.language.isoen
dc.relation.haspartJournal of the Royal Society Interface
dc.relation.isreferencedbyThe Royal Society
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectSRS-XRF
dc.subjectarchosaur
dc.subjecthistology
dc.subjectbone
dc.subjectfracture healing
dc.titleSynchrotron imaging reveals bone healing and remodelling strategies in extinct and extant vertebrates
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1098/rsif.2014.0277
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-31T17:02:23Z
refterms.dateFOA2021-01-31T17:02:28Z


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