Synthesis and properties of lysosome-specific photoactivatable probes for live-cell imaging
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Journal ArticleDate
2015-08-01Author
Tran, MNRarig, RAF
Chenoweth, DM
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http://hdl.handle.net/20.500.12613/5250
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10.1039/c5sc01601kAbstract
© The Royal Society of Chemistry. Fluorescent dyes have become increasingly important in cell biology since they enable high signal-to-noise and selectivity in visualizing subcellular organelles. Photoactivatable dyes allow for tracking and monitoring of a subset of cells or organelles. Here, we report the synthesis and application of a new class of large Stokes shift fluorescent dyes that are water-soluble, cell permeable, non-cytotoxic, and lysosome-specific. Additionally, we demonstrate temporally controlled sequential photoactivation of individual cells in close spatial proximity.Citation to related work
Royal Society of Chemistry (RSC)Has part
Chemical ScienceADA compliance
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http://dx.doi.org/10.34944/dspace/5232