Synthesis and properties of lysosome-specific photoactivatable probes for live-cell imaging
Permanent link to this recordhttp://hdl.handle.net/20.500.12613/5250
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Abstract© The Royal Society of Chemistry. Fluorescent dyes have become increasingly important in cell biology since they enable high signal-to-noise and selectivity in visualizing subcellular organelles. Photoactivatable dyes allow for tracking and monitoring of a subset of cells or organelles. Here, we report the synthesis and application of a new class of large Stokes shift fluorescent dyes that are water-soluble, cell permeable, non-cytotoxic, and lysosome-specific. Additionally, we demonstrate temporally controlled sequential photoactivation of individual cells in close spatial proximity.
Citation to related workRoyal Society of Chemistry (RSC)
Has partChemical Science
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