Annual report to the nation on the status of cancer, 1975-2011, featuring incidence of breast cancer subtypes by race/ethnicity, poverty, and state
Genre
Journal ArticleDate
2015-06-01Author
Kohler, BASherman, RL
Howlader, N
Jemal, A
Ryerson, AB
Henry, KA
Boscoe, FP
Cronin, KA
Lake, A
Noone, AM
Henley, SJ
Eheman, CR
Anderson, RN
Penberthy, L
Subject
AdultAfrican Americans
Age Distribution
Aged
Aged, 80 and over
Biomarkers, Tumor
Breast Neoplasms
Breast Neoplasms, Male
Confounding Factors, Epidemiologic
Continental Population Groups
Early Detection of Cancer
Ethnic Groups
European Continental Ancestry Group
Female
Hispanic Americans
Humans
Incidence
Male
Mammography
Middle Aged
Neoplasm Staging
Poverty
Prognosis
Receptor, ErbB-2
Receptors, Estrogen
Receptors, Progesterone
Registries
United States
Permanent link to this record
http://hdl.handle.net/20.500.12613/5234
Metadata
Show full item recordDOI
10.1093/jnci/djv048Abstract
© 2015 The Author 2015. Published by Oxford University Press. Background: The American Cancer Society (ACS), Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and North American Association of Central Cancer Registries (NAACCR) collaborate annually to produce updated, national cancer statistics. This Annual Report includes a focus on breast cancer incidence by subtype using new, national-level data. Methods: Population-based cancer trends and breast cancer incidence by molecular subtype were calculated. Breast cancer subtypes were classified using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. Results: Overall cancer incidence decreased for men by 1.8% annually from 2007 to 2011. Rates for women were stable from 1998 to 2011. Within these trends there was racial/ethnic variation, and some sites have increasing rates. Among children, incidence rates continued to increase by 0.8% per year over the past decade while, like adults, mortality declined. Overall mortality has been declining for both men and women since the early 1990's and for children since the 1970's. HR+/HER2- breast cancers, the subtype with the best prognosis, were the most common for all races/ethnicities with highest rates among non-Hispanic white women, local stage cases, and low poverty areas (92.7, 63.51, and 98.69 per 100000 non-Hispanic white women, respectively). HR+/HER2- breast cancer incidence rates were strongly, positively correlated with mammography use, particularly for non-Hispanic white women (Pearson 0.57, two-sided P <. 001). Triple-negative breast cancers, the subtype with the worst prognosis, were highest among non-Hispanic black women (27.2 per 100000 non-Hispanic black women), which is reflected in high rates in southeastern states. Conclusions: Progress continues in reducing the burden of cancer in the United States. There are unique racial/ethnic-specific incidence patterns for breast cancer subtypes; likely because of both biologic and social risk factors, including variation in mammography use. Breast cancer subtype analysis confirms the capacity of cancer registries to adjust national collection standards to produce clinically relevant data based on evolving medical knowledge.Citation to related work
Oxford University Press (OUP)Has part
Journal of the National Cancer InstituteADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.eduae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.34944/dspace/5216