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dc.creatorAlm, KH
dc.creatorRolheiser, T
dc.creatorMohamed, FB
dc.creatorOlson, IR
dc.date.accessioned2021-01-29T21:38:11Z
dc.date.available2021-01-29T21:38:11Z
dc.date.issued2015-06-18
dc.identifier.issn1662-5161
dc.identifier.issn1662-5161
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5204
dc.identifier.otherCK9WJ (isidoc)
dc.identifier.other26150776 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5222
dc.description.abstract© 2015 Alm, Rolheiser, Mohamed and Olson. Each day, we make hundreds of decisions. In some instances, these decisions are guided by our innate needs; in other instances they are guided by memory. Probabilistic reversal learning tasks exemplify the close relationship between decision making and memory, as subjects are exposed to repeated pairings of a stimulus choice with a reward or punishment outcome. After stimulus–outcome associations have been learned, the associated reward contingencies are reversed, and participants are not immediately aware of this reversal. Individual differences in the tendency to choose the previously rewarded stimulus reveal differences in the tendency to make poorly considered, inflexible choices. Lesion studies have strongly linked reversal learning performance to the functioning of the orbitofrontal cortex, the hippocampus, and in some instances, the amygdala. Here, we asked whether individual differences in the microstructure of the uncinate fasciculus, a white matter tract that connects anterior and medial temporal lobe regions to the orbitofrontal cortex, predict reversal learning performance. Diffusion tensor imaging and behavioral paradigms were used to examine this relationship in 33 healthy young adults. The results of tractography revealed a significant negative relationship between reversal learning performance and uncinate axial diffusivity, but no such relationship was demonstrated in a control tract, the inferior longitudinal fasciculus. Our findings suggest that the uncinate might serve to integrate associations stored in the anterior and medial temporal lobes with expectations about expected value based on feedback history, computed in the orbitofrontal cortex.
dc.format.extent343-
dc.language.isoeng
dc.relation.haspartFrontiers in Human Neuroscience
dc.relation.isreferencedbyFrontiers Media SA
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectorbitofrontal cortex
dc.subjecthippocampus
dc.subjectuncinate fasciculus
dc.subjectdiffusion imaging
dc.subjectreversal learning
dc.subjectdecision making
dc.titleFronto-temporal white matter connectivity predicts reversal learning errors
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.3389/fnhum.2015.00343
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-29T21:38:07Z
refterms.dateFOA2021-01-29T21:38:12Z


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