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dc.creatorWang, K
dc.creatorSeo, BR
dc.creatorFischbach, C
dc.creatorGourdon, D
dc.date.accessioned2021-01-29T21:18:01Z
dc.date.available2021-01-29T21:18:01Z
dc.date.issued2016-03-01
dc.identifier.issn1865-5025
dc.identifier.issn1865-5033
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5190
dc.identifier.otherDD8BL (isidoc)
dc.identifier.other26900407 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5208
dc.description.abstract© 2015, The Author(s). Fibronectin (Fn) is an essential extracellular matrix (ECM) glycoprotein involved in both physiological and pathological processes. The structure–function relationship of Fn has been and is still being studied, as changes in its molecular structure are integral in regulating (or dysregulating) its biological activities via its cell, matrix component, and growth factor binding sites. Fn comprises three types of repeating modules; among them, FnIII modules are mechanically unstable domains that may be extended/unfolded upon cell traction and either uncover cryptic binding sites or disrupt otherwise exposed binding sites. Cells assemble Fn into a fibrillar network; its conformational flexibility implicates Fn as a critical mechanoregulator of the ECM. Fn has been shown to contribute to altered stroma remodeling during tumorigenesis. This review will discuss (i) the significance of the structure–function relationship of Fn at both the molecular and the matrix scales, (ii) the role of Fn mechanobiology in the regulation of tumorigenesis, and (iii) Fn-related advances in cancer therapy development.
dc.format.extent1-11
dc.language.isoen
dc.relation.haspartCellular and Molecular Bioengineering
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFibronectin conformational flexibility
dc.subjectFibronectin mechanics
dc.subjectTumor stroma
dc.subjectTumor progression
dc.titleFibronectin Mechanobiology Regulates Tumorigenesis
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.1007/s12195-015-0417-4
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidWang, Karin|0000-0001-7812-2583
dc.date.updated2021-01-29T21:17:57Z
refterms.dateFOA2021-01-29T21:18:01Z


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