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dc.creatorArtimovich, E
dc.creatorKapito-Tembo, A
dc.creatorPensulo, P
dc.creatorNyirenda, O
dc.creatorBrown, S
dc.creatorJoshi, S
dc.creatorTaylor, TE
dc.creatorMathanga, D
dc.creatorEscalante, AA
dc.creatorLaufer, MK
dc.creatorTakala-Harrison, S
dc.date.accessioned2021-01-29T17:52:41Z
dc.date.available2021-01-29T17:52:41Z
dc.date.issued2015-10-05
dc.identifier.issn1475-2875
dc.identifier.issn1475-2875
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5171
dc.identifier.other26437774 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5189
dc.description.abstract© 2015 Artimovich et al. Background: Persistence of sulfadoxine-pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods: Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity (He) was estimated to evaluate genetic diversity. Results: No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in He flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions: The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence.
dc.format.extent387-
dc.language.isoen
dc.relation.haspartMalaria Journal
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMalaria
dc.subjectSulfadoxine-pyrimethamine
dc.subjectResistance
dc.subjectSelective sweeps
dc.subjectDihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS)
dc.titleThe effect of local variation in malaria transmission on the prevalence of sulfadoxine-pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1186/s12936-015-0860-7
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-29T17:52:37Z
refterms.dateFOA2021-01-29T17:52:42Z


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