Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
Genre
Journal ArticleDate
2015-10-19Author
Yang, JHuang, T
Petralia, F
Long, Q
Zhang, B
Argmann, C
Zhao, Y
Mobbs, CV
Schadt, EE
Zhu, J
Tu, Z
Ardlie, KG
Deluca, DS
Segrè, AV
Sullivan, TJ
Young, TR
Gelfand, ET
Trowbridge, CA
Maller, JB
Tukiainen, T
Lek, M
Ward, LD
Kheradpour, P
Iriarte, B
Meng, Y
Palmer, CD
Winckler, W
Hirschhorn, J
Kellis, M
MacArthur, DG
Getz, G
Shablin, AA
Li, G
Zhou, YH
Nobel, AB
Rusyn, I
Wright, FA
Lappalainen, T
Ferreira, PG
Ongen, H
Rivas, MA
Battle, A
Mostafavi, S
Monlong, J
Sammeth, M
Mele, M
Reverter, F
Goldman, J
Koller, D
Guigo, R
McCarthy, MI
Dermitzakis, ET
Gamazon, ER
Konkashbaev, A
Nicolae, DL
Cox, NJ
Flutre, T
Wen, X
Stephens, M
Pritchard, JK
Lin, L
Liu, J
Brown, A
Mestichelli, B
Tidwell, D
Lo, E
Salvatore, M
Shad, S
Thomas, JA
Lonsdale, JT
Choi, C
Karasik, E
Ramsey, K
Moser, MT
Foster, BA
Gillard, BM
Syron, J
Fleming, J
Magazine, H
Hasz, R
Walters, GD
Bridge, JP
Miklos, M
Sullivan, S
Barker, LK
Traino, H
Mosavel, M
Siminoff, LA
Valley, DR
Rohrer, DC
Jewel, S
Branton, P
Sobin, LH
Qi, L
Hariharan, P
Wu, S
Tabor, D
Shive, C
Smith, AM
Buia, SA
Subject
AdultAged
Aging
Animals
Cluster Analysis
Computational Biology
Female
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Genetic Association Studies
Humans
Male
Mice
Middle Aged
Molecular Sequence Annotation
Mutation
Organ Specificity
Young Adult
Permanent link to this record
http://hdl.handle.net/20.500.12613/5187
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10.1038/srep15145Abstract
Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.Citation to related work
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http://dx.doi.org/10.34944/dspace/5169