A Wireless Intracranial Brain Deformation Sensing System for Blast-Induced Traumatic Brain Injury
Genre
Journal ArticleDate
2015-11-20Author
Song, SRace, NS
Kim, A
Zhang, T
Shi, R
Ziaie, B
Subject
AnimalsBiosensing Techniques
Blast Injuries
Brain Diseases
Brain Injuries
Ferric Compounds
Humans
Magnetic Fields
Magnets
Motion
Nanoparticles
Rats
Reproducibility of Results
Sensitivity and Specificity
Silicone Elastomers
Wireless Technology
Permanent link to this record
http://hdl.handle.net/20.500.12613/5179
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10.1038/srep16959Abstract
Blast-induced traumatic brain injury (bTBI) has been linked to a multitude of delayed-onset neurodegenerative and neuropsychiatric disorders, but complete understanding of their pathogenesis remains elusive. To develop mechanistic relationships between bTBI and post-blast neurological sequelae, it is imperative to characterize the initiating traumatic mechanical events leading to eventual alterations of cell, tissue, and organ structure and function. This paper presents a wireless sensing system capable of monitoring the intracranial brain deformation in real-time during the event of a bTBI. The system consists of an implantable soft magnet and an external head-mounted magnetic sensor that is able to measure the field in three dimensions. The change in the relative position of the soft magnet WITH respect to the external sensor as the result of the blast wave induces changes in the magnetic field. The magnetic field data in turn is used to extract the temporal and spatial motion of the brain under the blast wave in real-time. The system has temporal and spatial resolutions of 5 μs and 10 μm. Following the characterization and validation of the sensor system, we measured brain deformations in a live rodent during a bTBI.Citation to related work
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http://dx.doi.org/10.34944/dspace/5161