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    YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION

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    Genre
    Thesis/Dissertation
    Date
    2019
    Author
    LaCanna, Ryan
    Advisor
    Tian, Ying
    Committee member
    Koch, Walter J.
    Drosatos, Konstantinos
    Kosmider, Beata
    Department
    Biomedical Sciences
    Subject
    Biology, Molecular
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/517
    
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    DOI
    http://dx.doi.org/10.34944/dspace/499
    Abstract
    Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery from these insults to rebuild the epithelial barrier and restore pulmonary functions. Here, we show that sublethal infection of mice with Streptococcus pneumonia, the most common pathogen of community-acquired pneumonia, led to exclusive damage in lung alveoli, followed by alveolar epithelial regeneration and resolution of lung inflammation. We show that surfactant protein C-expressing (SPC-expressing) alveolar epithelial type II cells (AECIIs) underwent proliferation and differentiation after infection, which contributes to the newly formed alveolar epithelium. This increase in AECII activities was correlated with increased nuclear expression of Yap and Taz, the mediators of the Hippo pathway. Mice that lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in
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