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dc.creatorFidoamore, A
dc.creatorCristiano, L
dc.creatorAntonosante, A
dc.creatorD'Angelo, M
dc.creatorDi Giacomo, E
dc.creatorAstarita, C
dc.creatorGiordano, A
dc.creatorIppoliti, R
dc.creatorBenedetti, E
dc.creatorCimini, A
dc.date.accessioned2021-01-29T17:08:05Z
dc.date.available2021-01-29T17:08:05Z
dc.date.issued2016-01-01
dc.identifier.issn1687-966X
dc.identifier.issn1687-9678
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5146
dc.identifier.otherDH2WE (isidoc)
dc.identifier.other26880981 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5164
dc.description.abstract© 2016 Alessia Fidoamore et al. Among all solid tumors, the high-grade glioma appears to be the most vascularized one. In fact, "microvascular hyperplasia" is a hallmark of GBM. An altered vascular network determines irregular blood flow, so that tumor cells spread rapidly beyond the diffusion distance of oxygen in the tissue, with the consequent formation of hypoxic or anoxic areas, where the bulk of glioblastoma stem cells (GSCs) reside. The response to this event is the induction of angiogenesis, a process mediated by hypoxia inducible factors. However, this new capillary network is not efficient in maintaining a proper oxygen supply to the tumor mass, thereby causing an oxygen gradient within the neoplastic zone. This microenvironment helps GSCs to remain in a "quiescent" state preserving their potential to proliferate and differentiate, thus protecting them by the effects of chemo-and radiotherapy. Recent evidences suggest that responses of glioblastoma to standard therapies are determined by the microenvironment of the niche, where the GSCs reside, allowing a variety of mechanisms that contribute to the chemo-and radioresistance, by preserving GSCs. It is, therefore, crucial to investigate the components/factors of the niche in order to formulate new adjuvant therapies rendering more efficiently the gold standard therapies for this neoplasm.
dc.format.extent1-17
dc.language.isoen
dc.relation.haspartStem Cells International
dc.relation.isreferencedbyHindawi Limited
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject1112 Oncology and Carcinogenesis
dc.subjectBiomedical
dc.subjectBasic Science
dc.subjectCancer
dc.subjectNeurosciences
dc.subjectStem Cell Research
dc.subjectBrain Cancer
dc.subjectRare Diseases
dc.subjectBrain Disorders
dc.subjectOrphan Drug
dc.subjectCancer
dc.subject2.1 Biological and endogenous factors
dc.titleGlioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1155/2016/6809105
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidGiordano, Antonio|0000-0002-5959-016X
dc.date.updated2021-01-29T17:08:01Z
refterms.dateFOA2021-01-29T17:08:05Z


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