Characterizing the malaria rural-to-urban transmission interface: The importance of reactive case detection
Genre
Journal ArticleDate
2017-07-17Author
Molina Gómez, KCaicedo, MA
Gaitán, A
Herrera-Varela, M
Arce, MI
Vallejo, AF
Padilla, J
Chaparro, P
Pacheco, MA
Escalante, AA
Arevalo-Herrera, M
Herrera, S
Subject
AdolescentAdult
Animals
Anopheles
Child
Colombia
Cross-Sectional Studies
Diagnostic Tests, Routine
Disease Transmission, Infectious
Female
Genetic Variation
Genotype
Humans
Interviews as Topic
Malaria
Male
Microscopy
Middle Aged
Molecular Epidemiology
Mosquito Vectors
Plasmodium
Polymerase Chain Reaction
Prevalence
Risk Factors
Rural Population
Urban Population
Young Adult
Permanent link to this record
http://hdl.handle.net/20.500.12613/5125
Metadata
Show full item recordDOI
10.1371/journal.pntd.0005780Abstract
© 2017 Molina Gómez et al. Background: Reported urban malaria cases are increasing in Latin America, however, evidence of such trend remains insufficient. Here, we propose an integrated approach that allows characterizing malaria transmission at the rural-to-urban interface by combining epidemiological, entomological, and parasite genotyping methods. Methods/Principal findings: A descriptive study that combines active (ACD), passive (PCD), and reactive (RCD) case detection was performed in urban and peri-urban neighborhoods of Quibdó, Colombia. Heads of households were interviewed and epidemiological surveys were conducted to assess malaria prevalence and identify potential risk factors. Sixteen primary cases, eight by ACD and eight by PCD were recruited for RCD. Using the RCD strategy, prevalence of 1% by microscopy (6/604) and 9% by quantitative polymerase chain reaction (qPCR) (52/604) were found. A total of 73 houses and 289 volunteers were screened leading to 41 secondary cases, all of them in peri-urban settings (14% prevalence). Most secondary cases were genetically distinct from primary cases indicating that there were independent occurrences. Plasmodium vivax was the predominant species (76.3%, 71/93), most of them being asymptomatic (46/71). Urban and peri-urban neighborhoods had significant sociodemographic differences. Twenty-four potential breeding sites were identified, all in peri-urban areas. The predominant vectors for 1,305 adults were Anopheles nuneztovari (56,2%) and An. Darlingi (42,5%). One An. nuneztovari specimen was confirmed naturally infected with P. falciparum by ELISA. Conclusions: This study found no evidence supporting the existence of urban malaria transmission in Quibdó. RCD strategy was more efficient for identifying malaria cases than ACD alone in areas where malaria transmission is variable and unstable. Incorporating parasite genotyping allows discovering hidden patterns of malaria transmission that cannot be detected otherwise. We propose to use the term “focal case” for those primary cases that lead to discovery of secondary but genetically unrelated malaria cases indicating undetected malaria transmission.Citation to related work
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http://dx.doi.org/10.34944/dspace/5107