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dc.creatorChen, D
dc.creatorStrang, JF
dc.creatorKolbuck, VD
dc.creatorRosenthal, SM
dc.creatorWallen, K
dc.creatorWaber, DP
dc.creatorSteinberg, L
dc.creatorSisk, CL
dc.creatorRoss, J
dc.creatorPaus, T
dc.creatorMueller, SC
dc.creatorMccarthy, MM
dc.creatorMicevych, PE
dc.creatorMartin, CL
dc.creatorKreukels, BPC
dc.creatorKenworthy, L
dc.creatorHerting, MM
dc.creatorHerlitz, A
dc.creatorHaraldsen, IRJH
dc.creatorDahl, R
dc.creatorCrone, EA
dc.creatorChelune, GJ
dc.creatorBurke, SM
dc.creatorBerenbaum, SA
dc.creatorBeltz, AM
dc.creatorBakker, J
dc.creatorEliot, L
dc.creatorVilain, E
dc.creatorWallace, GL
dc.creatorNelson, EE
dc.creatorGarofalo, R
dc.date.accessioned2021-01-28T21:09:13Z
dc.date.available2021-01-28T21:09:13Z
dc.date.issued2020-12-01
dc.identifier.issn2688-4887
dc.identifier.issn2380-193X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5082
dc.identifier.otherPMC7759272 (pmc)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5100
dc.description.abstract© Diane Chen et al. 2020: Published by Mary Ann Liebert, Inc. Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pubertal suppression improves mental health functioning. Given the widespread changes in brain and cognition that occur during puberty, a critical question is whether this treatment impacts neurodevelopment. Methods: A Delphi consensus procedure engaged 24 international experts in neurodevelopment, gender development, puberty/adolescence, neuroendocrinology, and statistics/psychometrics to identify priority research methodologies to address the empirical question: is pubertal suppression treatment associated with real-world neurocognitive sequelae? Recommended study approaches reaching 80% consensus were included in the consensus parameter. Results: The Delphi procedure identified 160 initial expert recommendations, 44 of which ultimately achieved consensus. Consensus study design elements include the following: a minimum of three measurement time points, pubertal staging at baseline, statistical modeling of sex in analyses, use of analytic approaches that account for heterogeneity, and use of multiple comparison groups to minimize the limitations of any one group. Consensus study comparison groups include untreated transgender youth matched on pubertal stage, cisgender (i.e., gender congruent) youth matched on pubertal stage, and an independent sample from a large-scale youth development database. The consensus domains for assessment includes: mental health, executive function/cognitive control, and social awareness/functioning. Conclusion: An international interdisciplinary team of experts achieved consensus around primary methods and domains for assessing neurodevelopmental effects (i.e., benefits and/or difficulties) of pubertal suppression treatment in transgender youth.
dc.format.extent246-257
dc.language.isoen
dc.relation.haspartTransgender Health
dc.relation.isreferencedbyMary Ann Liebert Inc
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.subjectDelphi
dc.subjectGnRHa
dc.subjectadolescents
dc.subjectexpert consensus
dc.subjectpuberty blockers
dc.subjecttransgender
dc.titleConsensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1089/trgh.2020.0006
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-28T21:09:10Z
refterms.dateFOA2021-01-28T21:09:13Z


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