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dc.creatorChung, WY
dc.creatorWadhawan, S
dc.creatorSzklarczyk, R
dc.creatorPond, SK
dc.creatorNekrutenko, A
dc.date.accessioned2021-01-28T20:36:49Z
dc.date.available2021-01-28T20:36:49Z
dc.date.issued2007-05-01
dc.identifier.issn1553-734X
dc.identifier.issn1553-7358
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5076
dc.identifier.other17511511 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5094
dc.description.abstractCoding of multiple proteins by overlapping reading frames is not a feature one would associate with eukaryotic genes. Indeed, codependency between codons of overlapping protein-coding regions imposes a unique set of evolutionary constraints, making it a costly arrangement. Yet in cases of tightly coexpressed interacting proteins, dual coding may be advantageous. Here we show that although dual coding is nearly impossible by chance, a number of human transcripts contain overlapping coding regions. Using newly developed statistical techniques, we identified 40 candidate genes with evolutionarily conserved overlapping coding regions. Because our approach is conservative, we expect mammals to possess more dual-coding genes. Our results emphasize that the skepticism surrounding eukaryotic dual coding is unwarranted: rather than being artifacts, overlapping reading frames are often hallmarks of fascinating biology. © 2007 Chung et al.
dc.format.extent0855-0861
dc.language.isoen
dc.relation.haspartPLoS Computational Biology
dc.relation.isreferencedbyPublic Library of Science (PLoS)
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectChromosome Mapping
dc.subjectComputer Simulation
dc.subjectHumans
dc.subjectMammals
dc.subjectModels, Genetic
dc.subjectMolecular Sequence Data
dc.subjectMultigene Family
dc.subjectOpen Reading Frames
dc.subjectRNA Splice Sites
dc.subjectSequence Analysis, DNA
dc.titleA first look at ARFome: Dual-coding genes in mammalian genomes
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1371/journal.pcbi.0030091
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidPond, Sergei L. Kosakovsky|0000-0003-4817-4029
dc.date.updated2021-01-28T20:36:47Z
refterms.dateFOA2021-01-28T20:36:50Z


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