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dc.creatorSlavov, N
dc.creatorAiroldi, EM
dc.creatorVan Oudenaarden, A
dc.creatorBotstein, D
dc.date.accessioned2021-01-28T20:34:16Z
dc.date.available2021-01-28T20:34:16Z
dc.date.issued2012-05-15
dc.identifier.issn1059-1524
dc.identifier.issn1939-4586
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5074
dc.identifier.other22456505 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5092
dc.description.abstractThe respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases that are most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC). Each phase is associated with the periodic expression of thousands of genes, producing oscillating patterns of gene expression found in synchronized cultures and in single cells of slowly growing unsynchronized cultures. Systematic variation in the durations of the HOC and LOC phases can account quantitatively for well-studied transcriptional responses to growth rate differences. Here we show that a similar mechanism - transitions from the HOC phase to the LOC phase - can account for much of the common environmental stress response (ESR) and for the cross-protection by a preliminary heat stress (or slow growth rate) to subsequent lethal heat stress. Similar to the budding yeast metabolic cycle, we suggest that a metabolic cycle, coupled in a similar way to the ESR, in the distantly related fission yeast, Schizosaccharomyces pombe, and in humans can explain gene expression and respiratory patterns observed in these eukaryotes. Although metabolic cycling is associated with the G0/G1 phase of the cell division cycle of slowly growing budding yeast, transcriptional cycling was detected in the G2 phase of the division cycle in fission yeast, consistent with the idea that respiratory metabolic cycling occurs during the phases of the cell division cycle associated with mass accumulation in these divergent eukaryotes. © 2012 Slavov et al.
dc.format.extent1986-1997
dc.language.isoen
dc.relation.haspartMolecular Biology of the Cell
dc.relation.isreferencedbyAmerican Society for Cell Biology (ASCB)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0
dc.subjectCell Cycle
dc.subjectCells, Cultured
dc.subjectCluster Analysis
dc.subjectEnvironment
dc.subjectEpithelial Cells
dc.subjectFibroblasts
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation
dc.subjectHeat-Shock Response
dc.subjectHumans
dc.subjectMetabolic Networks and Pathways
dc.subjectMultigene Family
dc.subjectOligonucleotide Array Sequence Analysis
dc.subjectOxygen Consumption
dc.subjectPrimary Cell Culture
dc.subjectSaccharomyces cerevisiae
dc.titleA conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1091/mbc.E11-11-0961
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidAiroldi, Edoardo|0000-0002-3512-0542
dc.date.updated2021-01-28T20:34:12Z
refterms.dateFOA2021-01-28T20:34:17Z


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