Norovirus infection and acquired immunity in 8 countries: Results from the MAL-ED study
dc.creator | Rouhani, S | |
dc.creator | Peñataro Yori, P | |
dc.creator | Paredes Olortegui, M | |
dc.creator | Siguas Salas, M | |
dc.creator | Rengifo Trigoso, D | |
dc.creator | Mondal, D | |
dc.creator | Bodhidatta, L | |
dc.creator | Platts-Mills, J | |
dc.creator | Samie, A | |
dc.creator | Kabir, F | |
dc.creator | Lima, AAM | |
dc.creator | Babji, S | |
dc.creator | Mason, CJ | |
dc.creator | Kalam, A | |
dc.creator | Bessong, P | |
dc.creator | Ahmed, T | |
dc.creator | Mduma, E | |
dc.creator | Bhutta, ZA | |
dc.creator | Lima, I | |
dc.creator | Ramdass, R | |
dc.creator | Lang, D | |
dc.creator | George, A | |
dc.creator | Zaidi, AKM | |
dc.creator | Kang, G | |
dc.creator | Houpt, E | |
dc.creator | Kosek, MN | |
dc.creator | Brett, N | |
dc.creator | Acosta, AM | |
dc.creator | De Burga, RR | |
dc.creator | Chavez, CB | |
dc.creator | Flores, JT | |
dc.creator | Olotegui, MP | |
dc.creator | Pinedo, SR | |
dc.creator | Salas, MS | |
dc.creator | Trigoso, DR | |
dc.creator | Vasquez, AO | |
dc.creator | Ahmed, I | |
dc.creator | Alam, D | |
dc.creator | Ali, A | |
dc.creator | Qureshi, S | |
dc.creator | Rasheed, M | |
dc.creator | Soofi, S | |
dc.creator | Turab, A | |
dc.creator | Bose, A | |
dc.creator | Hariraju, D | |
dc.creator | Jennifer, MS | |
dc.creator | John, S | |
dc.creator | Kaki, S | |
dc.creator | Karunakaran, P | |
dc.creator | Koshy, B | |
dc.creator | Lazarus, RP | |
dc.creator | Muliyil, J | |
dc.creator | Raghava, MV | |
dc.creator | Raju, S | |
dc.creator | Ramachandran, A | |
dc.creator | Ramadas, R | |
dc.creator | Ramanujam, K | |
dc.creator | Roshan, R | |
dc.creator | Sharma, SL | |
dc.creator | Shanmuga Sundaram, E | |
dc.creator | Thomas, RJ | |
dc.creator | Pan, WK | |
dc.creator | Ambikapathi, R | |
dc.creator | Carreon, JD | |
dc.creator | Charu, V | |
dc.creator | Doan, V | |
dc.creator | Graham, J | |
dc.creator | Hoest, C | |
dc.creator | Knobler, S | |
dc.creator | McCormick, BJJ | |
dc.creator | McGrath, M | |
dc.creator | Miller, MA | |
dc.creator | Mohale, A | |
dc.creator | Nayyar, G | |
dc.creator | Psaki, S | |
dc.creator | Rasmussen, Z | |
dc.creator | Richard, SA | |
dc.creator | Seidman, JC | |
dc.creator | Wang, V | |
dc.creator | Blank, R | |
dc.creator | Gottlieb, M | |
dc.creator | Tountas, KH | |
dc.creator | Amour, C | |
dc.creator | Bayyo, E | |
dc.creator | Mvungi, R | |
dc.creator | Nshama, R | |
dc.creator | Pascal, J | |
dc.creator | Swema, BM | |
dc.creator | Yarrot, L | |
dc.creator | Ahmed, AS | |
dc.creator | Haque, R | |
dc.creator | Hossain, I | |
dc.creator | Islam, M | |
dc.creator | Mahfuz, M | |
dc.creator | Tofail, F | |
dc.creator | Chandyo, RK | |
dc.creator | Shrestha, PS | |
dc.creator | Shrestha, R | |
dc.creator | Ulak, M | |
dc.creator | Bauck, A | |
dc.date.accessioned | 2021-01-27T22:01:19Z | |
dc.date.available | 2021-01-27T22:01:19Z | |
dc.date.issued | 2016-05-15 | |
dc.identifier.issn | 1058-4838 | |
dc.identifier.issn | 1537-6591 | |
dc.identifier.doi | http://dx.doi.org/10.34944/dspace/5052 | |
dc.identifier.other | 27013692 (pubmed) | |
dc.identifier.uri | http://hdl.handle.net/20.500.12613/5070 | |
dc.description.abstract | © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. Background. Norovirus is an important cause of childhood diarrhea. We present data from a longitudinal, multicountry study describing norovirus epidemiology during the first 2 years of life. Methods. A birth cohort of 1457 children across 8 countries contributed 7077 diarrheal stools for norovirus testing. A subset of 199 children contributed additional asymptomatic samples (2307) and diarrheal stools (770), which were used to derive incidence rates and evaluate evidence for acquired immunity. Results. Across sites, 89% of children experienced at least 1 norovirus infection before 24 months, and 22.7% of all diarrheal stools were norovirus positive. Severity of norovirus-positive diarrhea was comparable to other enteropathogens, with the exception of rotavirus. Incidence of genogroup II (GII) infection was higher than genogroup I and peaked at 6-11 months across sites. Undernutrition was a risk factor for symptomatic norovirus infection, with an increase in 1 standard deviation of length-for-age z score associated with a 17% reduction (odds ratio, 0.83 [95% confidence interval,. 72-.97]; P =. 011) in the odds of experiencing diarrhea when norovirus was present, after accounting for genogroup, rotavirus vaccine, and age. Evidence of acquired immunity was observed among GII infections only: Children with prior GII infection were found to have a 27% reduction in the hazard of subsequent infection (hazard ratio, 0.727; P =. 010). Conclusions. The high prevalence of norovirus across 8 sites in highly variable epidemiologic settings and demonstration of protective immunity for GII infections provide support for investment in vaccine development. | |
dc.format.extent | 1210-1217 | |
dc.language.iso | en | |
dc.relation.haspart | Clinical Infectious Diseases | |
dc.relation.isreferencedby | Oxford University Press (OUP) | |
dc.rights | CC BY-NC-ND | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | diarrhea | |
dc.subject | immunity | |
dc.subject | norovirus | |
dc.subject | Caliciviridae Infections | |
dc.subject | Child, Preschool | |
dc.subject | Cohort Studies | |
dc.subject | Diarrhea | |
dc.subject | Feces | |
dc.subject | Humans | |
dc.subject | Incidence | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Norovirus | |
dc.title | Norovirus infection and acquired immunity in 8 countries: Results from the MAL-ED study | |
dc.type | Article | |
dc.type.genre | Journal Article | |
dc.relation.doi | 10.1093/cid/ciw072 | |
dc.ada.note | For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu | |
dc.date.updated | 2021-01-27T22:01:15Z | |
refterms.dateFOA | 2021-01-27T22:01:20Z |