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dc.creatorCharles, JP
dc.creatorCappellari, O
dc.creatorSpence, AJ
dc.creatorHutchinson, JR
dc.creatorWells, DJ
dc.date.accessioned2021-01-27T21:55:32Z
dc.date.available2021-01-27T21:55:32Z
dc.date.issued2016-04-01
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5050
dc.identifier.other27115354 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5068
dc.description.abstract© 2016 Charles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Mice are one of the most commonly used laboratory animals, with an extensive array of disease models in existence, including for many neuromuscular diseases. The hindlimb is of particular interest due to several close muscle analogues/homologues to humans and other species. A detailed anatomical study describing the adult morphology is lacking, however. This study describes in detail the musculoskeletal geometry and skeletal muscle architecture of the mouse hindlimb and pelvis, determining the extent to which the muscles are adapted for their function, as inferred from their architecture. Using I2 KI enhanced microCT scanning and digital segmentation, it was possible to identify 39 distinct muscles of the hindlimb and pelvis belonging to nine functional groups. The architecture of each of these muscles was determined through microdissections, revealing strong architectural specialisations between the functional groups. The hip extensors and hip adductors showed significantly stronger adaptations towards high contraction velocities and joint control relative to the distal functional groups, which exhibited larger physiological cross sectional areas and longer tendons, adaptations for high force output and elastic energy savings. These results suggest that a proximo-distal gradient in muscle architecture exists in the mouse hindlimb. Such a gradient has been purported to function in aiding locomotor stability and efficiency. The data presented here will be especially valuable to any research with a focus on the architecture or gross anatomy of the mouse hindlimb and pelvis musculature, but also of use to anyone interested in the functional significance of muscle design in relation to quadrupedal locomotion.
dc.format.extente0147669-e0147669
dc.language.isoen
dc.relation.haspartPLoS ONE
dc.relation.isreferencedbyPublic Library of Science (PLoS)
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdaptation, Physiological
dc.subjectAnimals
dc.subjectFemale
dc.subjectHindlimb
dc.subjectImaging, Three-Dimensional
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectMuscle, Skeletal
dc.subjectMusculoskeletal Physiological Phenomena
dc.subjectMusculoskeletal System
dc.subjectX-Ray Microtomography
dc.titleMusculoskeletal geometry, muscle architecture and functional specialisations of the mouse hindlimb
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1371/journal.pone.0147669
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidSpence, Andrew|0000-0001-7352-0128
dc.date.updated2021-01-27T21:55:28Z
refterms.dateFOA2021-01-27T21:55:33Z


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