• Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research

      Carlton, JM; Volkman, SK; Uplekar, S; Hupalo, DN; Pereira Alves, JM; Cui, L; Donnelly, M; Roos, DS; Harb, OS; Acosta, M; Read, A; Ribolla, PEM; Singh, OP; Valecha, N; Wassmer, SC; Ferreira, M; Escalante, AA (2015-09-01)
      © The American Society of Tropical Medicine and Hygiene. The study of the three protagonists in malaria-the Plasmodium parasite, the Anopheles mosquito, and the human host-is key to developing methods to control and eventually eliminate the disease. Genomic technologies, including the recent development of next-generation sequencing, enable interrogation of this triangle to an unprecedented level of scrutiny, and promise exciting progress toward real-time epidemiology studies and the study of evolutionary adaptation. We discuss the use of genomics by the International Centers of Excellence for Malaria Research, a network of field sites and laboratories in malaria-endemic countries that undertake cutting-edge research, training, and technology transfer in malarious countries of the world.