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dc.creatorGau, MR
dc.creatorZdilla, MJ
dc.date.accessioned2021-01-25T21:48:09Z
dc.date.available2021-01-25T21:48:09Z
dc.date.issued2016-11-12
dc.identifier.issn1940-087X
dc.identifier.issn1940-087X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4976
dc.identifier.other27911386 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4994
dc.description.abstract© 2016 Journal of Visualized Experiments. Organolithium reagents are powerful tools in the synthetic chemist's toolbox. However, the extreme pyrophoric nature of the most reactive reagents warrants proper technique, thorough training, and proper personal protective equipment. To aid in the training of researchers using organolithium reagents, a thorough, step-by-step protocol for the safe and effective use of tert-butyllithium on an inert gas line or within a glovebox is described. As a model reaction, preparation of lithium tert-butyl amide by the reaction of tert-butyl amine with one equivalent of tert-butyl lithium is presented.
dc.language.isoen
dc.relation.haspartJournal of Visualized Experiments
dc.relation.isreferencedbyMyJove Corporation
dc.rightsCC BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectChemistry
dc.subjectIssue 117
dc.subjectOrganolithium
dc.subjectair-sensitive handling
dc.subjectglovebox
dc.subjectSchlenk line
dc.subjectsynthesis
dc.titleA protocol for safe lithiation reactions using organolithium reagents
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.3791/54705
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidZdilla, Michael|0000-0003-0212-2557
dc.date.updated2021-01-25T21:48:06Z
refterms.dateFOA2021-01-25T21:48:09Z


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