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dc.creatorXiao, Q
dc.creatorWang, Z
dc.creatorWilliams, D
dc.creatorLeowanawat, P
dc.creatorPeterca, M
dc.creatorSherman, SE
dc.creatorZhang, S
dc.creatorHammer, DA
dc.creatorHeiney, PA
dc.creatorKing, SR
dc.creatorMarkovitz, DM
dc.creatorAndré, S
dc.creatorGabius, HJ
dc.creatorKlein, ML
dc.creatorPercec, V
dc.date.accessioned2021-01-25T21:34:22Z
dc.date.available2021-01-25T21:34:22Z
dc.date.issued2016-12-28
dc.identifier.issn2374-7943
dc.identifier.issn2374-7951
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4971
dc.identifier.otherEG2HW (isidoc)
dc.identifier.other28058284 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4989
dc.description.abstract© 2016 American Chemical Society. Nonlamellar lipid arrangements, including cubosomes, appear in unhealthy cells, e.g., when they are subject to stress, starvation, or viral infection. The bioactivity of cubosomes-nanoscale particles exhibiting bicontinuous cubic structures-versus more common vesicles is an unexplored area due to lack of suitable model systems. Here, glycodendrimercubosomes (GDCs)-sugar-presenting cubosomes assembled from Janus glycodendrimers by simple injection into buffer-are proposed as mimics of biological cubic membranes. The bicontinuous cubic GDC architecture has been demonstrated by electron tomography. The stability of these GDCs in buffer enabled studies on lectin-dependent agglutination, revealing significant differences compared with the vesicular glycodendrimersome (GDS) counterpart. In particular, GDCs showed an increased activity toward concanavalin A, as well as an increased sensitivity and selectivity toward two variants of banana lectins, a wild-type and a genetically modified variant, which is not exhibited by GDSs. These results suggest that cells may adapt under unhealthy conditions by undergoing a transformation from lamellar to cubic membranes as a method of defense.
dc.format.extent943-953
dc.language.isoen
dc.relation.haspartACS Central Science
dc.relation.isreferencedbyAmerican Chemical Society (ACS)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
dc.subject0601 Biochemistry and Cell Biology
dc.subjectGeneric Health Relevance
dc.subject2.1 Biological and endogenous factors
dc.titleWhy do membranes of some unhealthy cells adopt a cubic architecture?
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1021/acscentsci.6b00284
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-25T21:34:18Z
refterms.dateFOA2021-01-25T21:34:23Z


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