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dc.creatorRusso, A
dc.creatorFranchina, T
dc.creatorRicciardi, GRR
dc.creatorFanizza, C
dc.creatorScimone, A
dc.creatorChiofalo, G
dc.creatorGiordano, A
dc.creatorAdamo, V
dc.date.accessioned2021-01-25T21:00:48Z
dc.date.available2021-01-25T21:00:48Z
dc.date.issued2017-01-01
dc.identifier.issn1949-2553
dc.identifier.issn1949-2553
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4957
dc.identifier.otherEJ5YP (isidoc)
dc.identifier.other28060728 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4975
dc.description.abstractEpidermal Growth Factor Receptor (EGFR) mutated Non Small Cell Lung Cancers (NSCLCs) are a molecularly subgroup of patients with peculiar clinic-pathological characteristics. Previous studies have suggested a possible interaction between oncogene status and metastatic behavior in non squamous NSCLCs with conflicting results. The aim of this study was to compare the different metastatic patterns, at baseline and during the course of the disease, in a cohort of 137 Caucasian patients with non-squamous NSCLC according to the EGFR mutational status and survival differences according to the different metastatic behavior. We observed unique metastatic distributions between EGFR-mutated and EGFR wild type non-squamous NSCLCs. These data support the hypothesis that tumor bio-molecular characteristics and genotype may influence the metastatic process in NSCLC and might help the development of enrichment strategies for tumor genotyping in these tumors, especially in the presence of limited tissue availability.
dc.format.extent8717-8725
dc.language.isoen
dc.relation.haspartOncotarget
dc.relation.isreferencedbyImpact Journals, LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectNSCLC
dc.subjectEGFR mutations
dc.subjectmetastatic spread
dc.subjectEGFR WT
dc.subjectbrain metastases
dc.titleInfluence of EGFR mutational status on metastatic behavior in non squamous non small cell lung cancer
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.18632/oncotarget.14427
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidGiordano, Antonio|0000-0002-5959-016X
dc.date.updated2021-01-25T21:00:44Z
refterms.dateFOA2021-01-25T21:00:49Z


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