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dc.creatorKatsura, Y
dc.creatorStanley, CE
dc.creatorKumar, S
dc.creatorNei, M
dc.date.accessioned2021-01-25T15:29:02Z
dc.date.available2021-01-25T15:29:02Z
dc.date.issued2017-01-01
dc.identifier.issn0737-4038
dc.identifier.issn1537-1719
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4948
dc.identifier.other28100791 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4966
dc.description.abstract© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. The reliability of a phylogenetic tree obtained from empirical data is usually measured by the bootstrap probability (Pb) of interior branches of the tree. If the bootstrap probability is high for most branches, the tree is considered to be reliable. If some interior branches show relatively low bootstrap probabilities, we are not sure that the inferred tree is really reliable. Here, we propose another quantity measuring the reliability of the tree called the stability of a subtree. This quantity refers to the probability of obtaining a subtree (Ps) of an inferred tree obtained. We then show that if the tree is to be reliable, both Pb and Ps must be high. We also show that Ps is given by a bootstrap probability of the subtree with the closest outgroup sequence, and computer program RESTA for computing the Pb and Ps values will be presented.
dc.format.extent718-723
dc.language.isoen
dc.relation.haspartMolecular Biology and Evolution
dc.relation.isreferencedbyOxford University Press (OUP)
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectphylogenetic trees
dc.subjectreliability
dc.subjectstability
dc.subjectsubtrees
dc.subjectbootstrap probability
dc.subjectMHC class II beta chain genes
dc.subjectcomputer program RESTA
dc.titleThe reliability and stability of an inferred phylogenetic tree from empirical data
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1093/molbev/msw272
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidKumar, Sudhir|0000-0002-9918-8212
dc.date.updated2021-01-25T15:28:59Z
refterms.dateFOA2021-01-25T15:29:02Z


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