Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system
Genre
Journal ArticleDate
2017-12-01Author
Tyburski, ALCheng, L
Assari, S
Darvish, K
Elliott, MB
Subject
Post-traumatic headacheMigraine
Concussion
Traumatic brain injury
Trigeminal
Microglia
Astrocytosis
Calcitonin gene-related peptide
Permanent link to this record
http://hdl.handle.net/20.500.12613/4956
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Show full item recordDOI
10.1186/s10194-017-0726-1Abstract
© 2017, The Author(s). Background: Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms. Methods: In this study, the acute effects of recovery between mild head injuries and the frequency of injuries on a headache behavior, trigeminal allodynia, was assessed using von Frey testing up to one week after injury, while histopathological changes in the trigeminal pain pathway were evaluated using western blot, ELISA and immunohistochemistry. Results: A decreased recovery time combined with an increased mild closed head injury (CHI) frequency results in reduced trigeminal allodynia thresholds compared to controls. The repetitive CHI group with the highest injury frequency showed the greatest reduction in trigeminal thresholds along with greatest increased levels of calcitonin gene-related peptide (CGRP) in the trigeminal nucleus caudalis. Repetitive CHI resulted in astrogliosis in the central trigeminal system, increased GFAP protein levels in the sensory barrel cortex, and an increased number of microglia cells in the trigeminal nucleus caudalis. Conclusions: Headache behavior in rats is dependent on the injury frequency and recovery interval between mild head injuries. A worsening of headache behavior after repetitive mild head injuries was concomitant with increases in CGRP levels, the presence of astrocytosis, and microglia proliferation in the central trigeminal pathway. Signaling between neurons and proliferating microglia in the trigeminal pain system may contribute to the initiation of acute headache after concussion or other traumatic brain injuries.Citation to related work
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Journal of Headache and PainADA compliance
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http://dx.doi.org/10.34944/dspace/4938