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dc.creatorMcDevitt, Jane
dc.creatorKrynetskiy, Evgeny
dc.date.accessioned2021-01-25T14:32:39Z
dc.date.available2021-01-25T14:32:39Z
dc.date.issued2017-03
dc.identifier.issn2056-3299
dc.identifier.issn2056-3299
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4924
dc.identifier.otherPMC6096436 (pmc)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4942
dc.description.abstractConcussion is a traumatic transient disturbance of the brain. In sport, the initial time and severity of concussion is known giving an opportunity for subsequent analysis. Variability in susceptibility and recovery between individual athletes depends, among other parameters, on genetic factors. The genes-encoding polypeptides that determine incidence, severity and prognosis for concussion are the primary candidates for genetic analysis. Genetic polymorphisms in the genes contributing to plasticity and repair (APOE), synaptic connectivity (GRIN2A), calcium influx (CACNA1E), uptake and deposit of glutamate (SLC17A7) are potential biomarkers of concussion incidence and recovery rate. With catalogued genetic variants, prospective genotyping of athletes at the beginning of their career will allow medical professionals to improve concussion management and return-to-play decisions.
dc.format.extentCNC26-CNC26
dc.language.isoen
dc.relation.haspartConcussion
dc.relation.isreferencedbyFuture Medicine Ltd
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMTBI
dc.subjectSNPs
dc.subjectTBI
dc.subjectsports medicine
dc.titleGenetic findings in sport-related concussions: potential for individualized medicine?
dc.typeArticle
dc.type.genreJournal Article
dc.type.genreReview
dc.relation.doi10.2217/cnc-2016-0020
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-25T14:32:34Z
refterms.dateFOA2021-01-25T14:32:39Z


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