Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound
Genre
Journal ArticleReview
Date
2017-03-24Author
Han, YanfuSun, Tianjun
Tao, Ran
Han, Yanqing
Liu, Jing
Subject
Mesenchymal stem cellsDiabetic wound
Advanced glycosylation end products
Wound healing
Application
Permanent link to this record
http://hdl.handle.net/20.500.12613/4920
Metadata
Show full item recordDOI
10.1186/s40001-017-0253-1Abstract
Nowadays, wound healing delay due to diabetes is considered to be closely related to the accumulation of advanced glycation end products (AGEs). Although mesenchymal stem cells (MSCs) exhibit positive effects on diabetic wound healing, related mechanisms are still not fully elucidated. It has been reported that MSCs can improve the activity of autophagy in injured tissues, thereby playing an important role in wound healing. The autophagy induced by MSCs may be beneficial to diabetic wound healing via removing AGEs, which provide new ideas for clinical treatment of diabetic wounds with the potential of broad application prospects. In this study, the current research situation and application prospect of umbilical cord-derived MSCs on the clearance of AGEs in diabetic wound were reviewed.Citation to related work
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http://dx.doi.org/10.34944/dspace/4902