Show simple item record

dc.creatorChothe, SK
dc.creatorBhushan, G
dc.creatorNissly, RH
dc.creatorYeh, YT
dc.creatorBrown, J
dc.creatorTurner, G
dc.creatorFisher, J
dc.creatorSewall, BJ
dc.creatorReeder, DM
dc.creatorTerrones, M
dc.creatorJayarao, BM
dc.creatorKuchipudi, SV
dc.date.accessioned2021-01-22T21:35:40Z
dc.date.available2021-01-22T21:35:40Z
dc.date.issued2017-12-01
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4893
dc.identifier.other28386114 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4911
dc.description.abstract© 2017 The Author(s). Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.
dc.format.extent660-
dc.language.isoen
dc.relation.haspartScientific Reports
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectChiroptera
dc.subjectFluorescent Antibody Technique
dc.subjectGene Expression
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectInfluenza A Virus, H1N1 Subtype
dc.subjectInfluenza A Virus, H5N2 Subtype
dc.subjectInfluenza A virus
dc.subjectNeuraminidase
dc.subjectOrthomyxoviridae Infections
dc.subjectReceptors, Cell Surface
dc.subjectReceptors, Virus
dc.subjectRespiratory Mucosa
dc.subjectVirus Attachment
dc.titleAvian and human influenza virus compatible sialic acid receptors in little brown bats
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1038/s41598-017-00793-6
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-22T21:35:36Z
refterms.dateFOA2021-01-22T21:35:41Z


Files in this item

Thumbnail
Name:
Avian and human influenza virus ...
Size:
1.996Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

CC BY
Except where otherwise noted, this item's license is described as CC BY