Avian and human influenza virus compatible sialic acid receptors in little brown bats
Genre
Journal ArticleDate
2017-12-01Author
Chothe, SKBhushan, G
Nissly, RH
Yeh, YT
Brown, J
Turner, G
Fisher, J
Sewall, BJ
Reeder, DM
Terrones, MJayarao, BMKuchipudi, SV
Subject
AnimalsChiroptera
Fluorescent Antibody Technique
Gene Expression
Humans
Immunohistochemistry
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H5N2 Subtype
Influenza A virus
NeuraminidaseOrthomyxoviridae InfectionsReceptors, Cell SurfaceReceptors, VirusRespiratory MucosaVirus Attachment
Permanent link to this record
http://hdl.handle.net/20.500.12613/4911Metadata
Show full item recordDOI
10.1038/s41598-017-00793-6Abstract
© 2017 The Author(s). Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.Citation to related work
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Scientific ReportsADA compliance
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Avian and human influenza virus compatible sialic acid receptors in little brown bats© 2017 The Author(s). Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.
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