Show simple item record

dc.creatorHung, J
dc.creatorBauer, A
dc.creatorGrossman, M
dc.creatorHamilton, RH
dc.creatorCoslett, HB
dc.creatorReilly, J
dc.date.accessioned2021-01-22T21:03:55Z
dc.date.available2021-01-22T21:03:55Z
dc.date.issued2017-05-16
dc.identifier.issn1662-5161
dc.identifier.issn1662-5161
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4880
dc.identifier.otherPMC5432627 (pmc)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4898
dc.description.abstract© 2017 Hung, Bauer, Grossman, Hamilton, Coslett and Reilly. We examined the effectiveness of a 2-week regimen of a semantic feature training in combination with transcranial direct current stimulation (tDCS) for progressive naming impairment associated with primary progressive aphasia (N = 4) or early onset Alzheimer’s Disease (N = 1). Patients received a 2-week regimen (10 sessions) of anodal tDCS delivered over the left temporoparietal cortex while completing a language therapy that consisted of repeated naming and semantic feature generation. Therapy targets consisted of familiar people, household items, clothes, foods, places, hygiene implements, and activities. Untrained items from each semantic category provided item level controls. We analyzed naming accuracies at multiple timepoints (i.e., pre-, post-, 6-month follow-up) via a mixed effects logistic regression and individual differences in treatment responsiveness using a series of non-parametric McNemar tests. Patients showed advantages for naming trained over untrained items. These gains were evident immediately post tDCS. Trained items also showed a shallower rate of decline over 6-months relative to untrained items that showed continued progressive decline. Patients tolerated stimulation well, and sustained improvements in naming accuracy suggest that the current intervention approach is viable. Future implementation of a sham control condition will be crucial toward ascertaining whether neuro stimulation and behavioral treatment act synergistically or alternatively whether treatment gains are exclusively attributable to either tDCS or the behavioral intervention.
dc.format.extent253-
dc.language.isoeng
dc.relation.haspartFrontiers in Human Neuroscience
dc.relation.isreferencedbyFrontiers Media SA
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectlanguage rehabilitation
dc.subjectnaming therapy
dc.subjectprimary progressive aphasia
dc.subjectsemantic feature analysis
dc.subjecttranscranial direct current stimulation (tDCS)
dc.titleSemantic feature training in combination with transcranial direct current stimulation (tDCS) for progressive anomia
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.3389/fnhum.2017.00253
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-22T21:03:52Z
refterms.dateFOA2021-01-22T21:03:56Z


Files in this item

Thumbnail
Name:
Semantic Feature Training in ...
Size:
889.0Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

CC BY
Except where otherwise noted, this item's license is described as CC BY