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dc.creatorHackett, K
dc.creatorKrikorian, R
dc.creatorGiovannetti, T
dc.creatorMelendez-Cabrero, J
dc.creatorRahman, A
dc.creatorCaesar, EE
dc.creatorChen, JL
dc.creatorHristov, H
dc.creatorSeifan, A
dc.creatorMosconi, L
dc.creatorIsaacson, RS
dc.date.accessioned2021-01-21T15:16:37Z
dc.date.available2021-01-21T15:16:37Z
dc.date.issued2018-01-01
dc.identifier.issn2352-8729
dc.identifier.issn2352-8729
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4789
dc.identifier.otherPMC6247399 (pmc)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4807
dc.description.abstract© 2018 The Authors Introduction: The NIH Toolbox Cognition Battery (NIHTB-CB) is a computer-based protocol not yet validated for clinical assessment. Methods: We administered the NIHTB-CB and traditional neuropsychological tests to 247 Memory Disorders and Alzheimer's Prevention Clinic patients with subjective cognitive decline, mild cognitive impairment, mild dementia due to Alzheimer's disease, and normal cognition. Principal component analysis, partial correlations, and univariate general linear model tests were performed to assess construct validity. Discriminant function analyses compared classification accuracy. Results: Principal component analysis identified three conceptually coherent factors: memory (MEMNIH), executive function (EFNIH), and crystallized intelligence (CINIH). These factors were strongly associated with corresponding traditional tests and differed across diagnostic groups as expected. Both NIHTB and traditional batteries yielded strong overall discriminative ability (>80%). Discussion: The NIHTB-CB is a valid method to assess neurocognitive domains pertinent to aging and dementia and has utility for applications in a memory clinic setting.
dc.format.extent764-772
dc.language.isoen
dc.relation.haspartAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
dc.relation.isreferencedbyWiley
dc.rightsCC BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectClinical assessment
dc.subjectDementia
dc.subjectMemory
dc.subjectNeuropsychology
dc.subjectTechnology
dc.subjectValidation
dc.titleUtility of the NIH Toolbox for assessment of prodromal Alzheimer's disease and dementia
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1016/j.dadm.2018.10.002
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-21T15:16:34Z
refterms.dateFOA2021-01-21T15:16:37Z


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