Show simple item record

dc.creatorChaudhry, SR
dc.creatorLwin, N
dc.creatorPhelan, D
dc.creatorEscalante, AA
dc.creatorBattistuzzi, FU
dc.date.accessioned2021-01-21T15:12:07Z
dc.date.available2021-01-21T15:12:07Z
dc.date.issued2018-12-01
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4786
dc.identifier.other29321589 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4804
dc.description.abstract© 2017 The Author(s). Low complexity regions (LCRs) are a common feature shared by many genomes, but their evolutionary and functional significance remains mostly unknown. At the core of the uncertainty is a poor understanding of the mechanisms that regulate their retention in genomes, whether driven by natural selection or neutral evolution. Applying a comparative approach of LCRs to multiple strains and species is a powerful approach to identify patterns of conservation in these regions. Using this method, we investigate the evolutionary history of LCRs in the genus Plasmodium based on orthologous protein coding genes shared by 11 species and strains from primate and rodent-infecting pathogens. We find multiple lines of evidence in support of natural selection as a major evolutionary force shaping the composition and conservation of LCRs through time and signatures that their evolutionary paths are species specific. Our findings add a comparative analysis perspective to the debate on the evolution of LCRs and harness the power of sequence comparisons to identify potential functionally important LCR candidates.
dc.format.extent335-
dc.language.isoen
dc.relation.haspartScientific Reports
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBase Composition
dc.subjectComputational Biology
dc.subjectConserved Sequence
dc.subjectEvolution, Molecular
dc.subjectGene Ontology
dc.subjectGenome, Protozoan
dc.subjectGenomics
dc.subjectPlasmodium
dc.titleComparative analysis of low complexity regions in Plasmodia
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1038/s41598-017-18695-y
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-21T15:12:03Z
refterms.dateFOA2021-01-21T15:12:08Z


Files in this item

Thumbnail
Name:
Comparative analysis of low ...
Size:
1.267Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

CC BY
Except where otherwise noted, this item's license is described as CC BY