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dc.creatorMelone, MAB
dc.creatorValentino, A
dc.creatorMargarucci, S
dc.creatorGalderisi, U
dc.creatorGiordano, A
dc.creatorPeluso, G
dc.date.accessioned2021-01-21T14:51:13Z
dc.date.available2021-01-21T14:51:13Z
dc.date.issued2018-02-01
dc.identifier.issn2041-4889
dc.identifier.issn2041-4889
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4776
dc.identifier.other29445084 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4794
dc.description.abstract© 2018 The Author(s). Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to support and enable rapid proliferation, continuous growth, and survival in hostile conditions. This dynamic character of the cellular metabolic network appears enhanced in cancer cells, in order to increase the adaptive phenotype and to maintain both viability and uncontrolled proliferation. Cancer cells can reprogram their metabolism to satisfy the energy as well as the biosynthetic intermediate request and to preserve their integrity from the harsh and hypoxic environment. Although several studies now recognize these reprogrammed activities as hallmarks of cancer, it remains unclear which are the pathways involved in regulating metabolic plasticity. Recent findings have suggested that carnitine system (CS) could be considered as a gridlock to finely trigger the metabolic flexibility of cancer cells. Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism. Therefore, the CS regulation, at both enzymatic and epigenetic levels, plays a pivotal role in tumors, suggesting new druggable pathways for prevention and treatment of human cancer.
dc.format.extent228-
dc.language.isoen
dc.relation.haspartCell Death and Disease
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiological Transport
dc.subjectCarnitine
dc.subjectCarnitine Acyltransferases
dc.subjectCarnitine O-Palmitoyltransferase
dc.subjectEnergy Metabolism
dc.subjectEpigenesis, Genetic
dc.subjectFatty Acids
dc.subjectGlucose
dc.subjectHumans
dc.subjectIsoenzymes
dc.subjectLipid Metabolism
dc.subjectMicroRNAs
dc.subjectMitochondria
dc.subjectNeoplasm Proteins
dc.subjectNeoplasms
dc.subjectSignal Transduction
dc.subjectTumor Cells, Cultured
dc.titleThe carnitine system and cancer metabolic plasticity review-article
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.1038/s41419-018-0313-7
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidGiordano, Antonio|0000-0002-5959-016X
dc.date.updated2021-01-21T14:51:09Z
refterms.dateFOA2021-01-21T14:51:13Z


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