The carnitine system and cancer metabolic plasticity review-article
Genre
ReviewJournal
Date
2018-02-01Author
Melone, MABValentino, A
Margarucci, S
Galderisi, U
Giordano, A
Peluso, G
Subject
Biological TransportCarnitine
Carnitine Acyltransferases
Carnitine O-Palmitoyltransferase
Energy Metabolism
Epigenesis, Genetic
Fatty Acids
Glucose
Humans
Isoenzymes
Lipid Metabolism
MicroRNAs
Mitochondria
Neoplasm Proteins
Neoplasms
Signal Transduction
Tumor Cells, Cultured
Permanent link to this record
http://hdl.handle.net/20.500.12613/4794
Metadata
Show full item recordDOI
10.1038/s41419-018-0313-7Abstract
© 2018 The Author(s). Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to support and enable rapid proliferation, continuous growth, and survival in hostile conditions. This dynamic character of the cellular metabolic network appears enhanced in cancer cells, in order to increase the adaptive phenotype and to maintain both viability and uncontrolled proliferation. Cancer cells can reprogram their metabolism to satisfy the energy as well as the biosynthetic intermediate request and to preserve their integrity from the harsh and hypoxic environment. Although several studies now recognize these reprogrammed activities as hallmarks of cancer, it remains unclear which are the pathways involved in regulating metabolic plasticity. Recent findings have suggested that carnitine system (CS) could be considered as a gridlock to finely trigger the metabolic flexibility of cancer cells. Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism. Therefore, the CS regulation, at both enzymatic and epigenetic levels, plays a pivotal role in tumors, suggesting new druggable pathways for prevention and treatment of human cancer.Citation to related work
Springer Science and Business Media LLCHas part
Cell Death and DiseaseADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.eduae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.34944/dspace/4776