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dc.contributor.advisorDanowsky, Joseph
dc.creatorZaidi, Hasan
dc.date.accessioned2020-10-05T20:49:13Z
dc.date.available2020-10-05T20:49:13Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.12613/475
dc.descriptionThis research project was completed as part of the course, Honors Technical Communication (ENGR 2996:001).
dc.description.abstractMillions of people around the world suffer from dry eye symptoms as a result of extended contact lens wear. The objective of this design document is to engineer a solution for chronic dry eyes. The solution must be safe, effective, easy to use, and affordable. The goal of the treatment is to decrease tear film osmolarity by 20 mOsmol/L. Three types of nanotechnologies were considered for this task. The candidate solutions were 1) hydrogel contact lenses infused with lubricant-loaded liposomes, 2) lubricantloaded microemulsions applied as eye drops, and 3) lubricant-loaded niosomes applied as eye drops. All solutions use polyethylene glycol 400 as the primary active ingredient in the lubricant. The three solutions provide a safe treatment option that allows increased bioavailability of drug and increased retention time, as well as controlled release of drug. A combination of candidates 1 and 3 – namely, hydrogel contact lenses infused with lubricant-loaded niosomes – seems to be the best solution because of excellent drug delivery kinetics and minimal safety concerns. The success of this project would encourage further research in niosome-based and contact lens-based drug delivery. It would also allow this company to expand research and development and further specialize in ocular drug delivery.
dc.format.extent20 pages
dc.languageEnglish
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTemple Undergraduate Research Prize Winners
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleUsing Nanoparticle Drug Delivery Mechanisms to Improve Eye Moisture Over Extended Periods of Contact Lens Wear
dc.typeText
dc.type.genreResearch project
dc.contributor.groupTemple University. Honors Program
dc.relation.doihttp://dx.doi.org/10.34944/dspace/457
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.awardLivingstone Undergraduate Research Award in STEM Disciplines
dc.description.schoolcollegeTemple University. College of Engineering
refterms.dateFOA2020-10-05T20:49:13Z


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