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    Using Nanoparticle Drug Delivery Mechanisms to Improve Eye Moisture Over Extended Periods of Contact Lens Wear

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    Genre
    Research project
    Date
    2017
    Author
    Zaidi, Hasan
    Advisor
    Danowsky, Joseph
    Group
    Temple University. Honors Program
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/475
    
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    DOI
    http://dx.doi.org/10.34944/dspace/457
    Abstract
    Millions of people around the world suffer from dry eye symptoms as a result of extended contact lens wear. The objective of this design document is to engineer a solution for chronic dry eyes. The solution must be safe, effective, easy to use, and affordable. The goal of the treatment is to decrease tear film osmolarity by 20 mOsmol/L. Three types of nanotechnologies were considered for this task. The candidate solutions were 1) hydrogel contact lenses infused with lubricant-loaded liposomes, 2) lubricantloaded microemulsions applied as eye drops, and 3) lubricant-loaded niosomes applied as eye drops. All solutions use polyethylene glycol 400 as the primary active ingredient in the lubricant. The three solutions provide a safe treatment option that allows increased bioavailability of drug and increased retention time, as well as controlled release of drug. A combination of candidates 1 and 3 – namely, hydrogel contact lenses infused with lubricant-loaded niosomes – seems to be the best solution because of excellent drug delivery kinetics and minimal safety concerns. The success of this project would encourage further research in niosome-based and contact lens-based drug delivery. It would also allow this company to expand research and development and further specialize in ocular drug delivery.
    Description
    This research project was completed as part of the course, Honors Technical Communication (ENGR 2996:001).
    ADA compliance
    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
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