STRUCTURAL AND FUNCTIONAL CEREBELLAR NETWORKS IN THEORY OF MIND

Abstract

Theory of Mind (ToM) is the ability to infer mental states of others and this skill relies on a distributed network of brain regions. A brain region that has been traditionally disregarded in relation to non-motor functions is the cerebellum. Here, we leveraged large-scale multimodal neuroimaging data to elucidate the structural and functional role of the cerebellum in ToM. We used functional activations to determine whether the cerebellum has a domain-general or domain-specific functional role. We found that the cerebellum is organized in a domain-specific way. We used effective connectivity and probabilistic tractography to map the cerebello-cerebral ToM network. We found a left cerebellar effective and structural lateralization, with more and stronger effective connections from the left cerebellar hemisphere to the contralateral cerebral ToM areas and greater cerebello-thalamo-cortical (CTC) and cortico-ponto-cerebellar (CPC) streamline counts from and to the left cerebellum. Lastly, we examined the relationship between CTC and CPC white matter and ToM speed and accuracy but found no correlation. Our study provides novel insights to the network organization of the cerebellum, an overlooked brain structure, and ToM, one of humans’ most essential abilities to navigate the social world.