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    Neutral theory and rapidly evolving viral pathogens

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    Name:
    Neutral Theory and Rapidly ...
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    Genre
    Journal Article
    Date
    2018-06-01
    Author
    Frost, SDW
    Magalis, BR
    Kosakovsky Pond, SL
    Subject
    HIV
    Influenza A virus
    neutral theory
    natural selection
    population structure
    molecular clock
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/4677
    
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    DOI
    10.1093/molbev/msy088
    Abstract
    © The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. The evolution of viral pathogens is shaped by strong selective forces that are exerted during jumps to new hosts, confrontations with host immune responses and antiviral drugs, and numerous other processes. However, while undeniably strong and frequent, adaptive evolution is largely confined to small parts of information-packed viral genomes, and the majority of observed variation is effectively neutral. The predictions and implications of the neutral theory have proven immensely useful in this context, with applications spanning understanding within-host population structure, tracing the origins and spread of viral pathogens, predicting evolutionary dynamics, andmodeling the emergence of drug resistance.We highlight the multiple ways in which the neutral theory has had an impact, which has been accelerated in the age of high-throughput, high-resolution genomics.
    Citation to related work
    Oxford University Press (OUP)
    Has part
    Molecular Biology and Evolution
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/4659
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