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dc.creatorMoore, AR
dc.creatorRichards, SE
dc.creatorKenny, K
dc.creatorRoyer, L
dc.creatorChan, U
dc.creatorFlavahan, K
dc.creatorVan Hooser, SD
dc.creatorParadis, S
dc.date.accessioned2021-01-14T16:58:36Z
dc.date.available2021-01-14T16:58:36Z
dc.date.issued2018-05-29
dc.identifier.issn2050-084X
dc.identifier.issn2050-084X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4640
dc.identifier.other29809135 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4658
dc.description.abstract© Moore et al. Sensory experience plays an important role in shaping neural circuitry by affecting the synaptic connectivity and intrinsic properties of individual neurons. Identifying the molecular players responsible for converting external stimuli into altered neuronal output remains a crucial step in understanding experience-dependent plasticity and circuit function. Here, we investigate the role of the activity-regulated, non-canonical Ras-like GTPase Rem2 in visual circuit plasticity. We demonstrate that Rem2 -/- mice fail to exhibit normal ocular dominance plasticity during the critical period. At the cellular level, our data establish a cell-autonomous role for Rem2 in regulating intrinsic excitability of layer 2/3 pyramidal neurons, prior to changes in synaptic function. Consistent with these findings, both in vitro and in vivo recordings reveal increased spontaneous firing rates in the absence of Rem2. Taken together, our data demonstrate that Rem2 is a key molecule that regulates neuronal excitability and circuit function in the context of changing sensory experience.
dc.format.extente33092-
dc.language.isoen
dc.relation.hasparteLife
dc.relation.isreferencedbyeLife Sciences Publications, Ltd
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectRem2
dc.subjectactivity-dependent
dc.subjecthomeostasis
dc.subjectintrinsic excitability
dc.subjectmouse
dc.subjectneuroscience
dc.subjectplasticity
dc.subjectAction Potentials
dc.subjectAnimals
dc.subjectFemale
dc.subjectGene Expression Regulation
dc.subjectMale
dc.subjectMice
dc.subjectMice, Knockout
dc.subjectMonomeric GTP-Binding Proteins
dc.subjectNerve Net
dc.subjectNeuronal Plasticity
dc.subjectPrimary Cell Culture
dc.subjectPyramidal Cells
dc.subjectRats
dc.subjectSensory Receptor Cells
dc.subjectSynapses
dc.subjectVisual Cortex
dc.titleRem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.7554/eLife.33092
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidMoore, Anna|0000-0001-6183-906X
dc.date.updated2021-01-14T16:58:32Z
refterms.dateFOA2021-01-14T16:58:37Z


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